monacolin X

isolated from Monaseus ruber; MF: C24-H34-O6; structure given in first source

Also Known As:

Butanoic acid, 2-methyl-3-oxo-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        monacolin X: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - monacolin X: 3

Experts

1.	B, Sambhavi: 1 article (08/2019)
2.	Balakrishnan, Anandan: 1 article (08/2019)
3.	Chatterjee, Suvro: 1 article (08/2019)
4.	Katakia, Yash T: 1 article (08/2019)
5.	Madan Kumar, Arumugam: 1 article (08/2019)
6.	Nagabhishek, Sirpu Natesh: 1 article (08/2019)
7.	Nagasundaram, Nagarajan: 1 article (08/2019)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 06/01/1993 - "The time course of the inhibition of cholesterol synthesis by low and high doses of mevinolin and monacolin X were studied in normal human skin fibroblasts, fibroblasts without low density lipoprotein receptor and HepG2 hepatoma cells. " 11/01/1990 - "We have investigated the effect of six compactin-related compounds--mevinolin, compactin, ML-236A, monacolin X, monacolin L and dihydromonacolin L--on cholesterol synthesis in human umbilical vein endothelial cells, human small intestine epithelial cells, human hepatoma cell line HEP G2, normal human skin fibroblasts and in skin fibroblasts from a patient with familial homozygous hypercholesterolemia. "
2.	Neoplasms (Cancer) 08/23/2019 - "Monacolin X showed reduced protein expression of pVEGFR2, pAKT1, pMAPKAPK2, pFAK and pERK1 in breast cancer lines and in DMBA induced mammary carcinoma in SD rats showed tumor regression and anti-angiogenesis ability via decrease pVEGFR2 and pAKT1 protein expression. "
3.	Hypercholesterolemia 11/01/1990 - "We have investigated the effect of six compactin-related compounds--mevinolin, compactin, ML-236A, monacolin X, monacolin L and dihydromonacolin L--on cholesterol synthesis in human umbilical vein endothelial cells, human small intestine epithelial cells, human hepatoma cell line HEP G2, normal human skin fibroblasts and in skin fibroblasts from a patient with familial homozygous hypercholesterolemia. "
4.	Carcinoma (Carcinomatosis) 08/23/2019 - "Monacolin X showed reduced protein expression of pVEGFR2, pAKT1, pMAPKAPK2, pFAK and pERK1 in breast cancer lines and in DMBA induced mammary carcinoma in SD rats showed tumor regression and anti-angiogenesis ability via decrease pVEGFR2 and pAKT1 protein expression. "
5.	Breast Neoplasms (Breast Cancer) 08/23/2019 - "Monacolin X showed reduced protein expression of pVEGFR2, pAKT1, pMAPKAPK2, pFAK and pERK1 in breast cancer lines and in DMBA induced mammary carcinoma in SD rats showed tumor regression and anti-angiogenesis ability via decrease pVEGFR2 and pAKT1 protein expression. "

Related Drugs and Biologics

1.	Lovastatin (Mevacor)
2.	Cholesterol
3.	LDL Receptors (LDL Receptor)
4.	Proteins (Proteins, Gene)
5.	monacolin L
6.	dihydromonacolin L
7.	ML 236A
8.	mevastatin (CS 500)