5,6,7,8-tetrahydropteridine
enzyme cofactor for certain oxidoreductases
Also Known As:
tetrahydropteridine
Networked: 8
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Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Neuroblastoma
12/01/1996
- " We investigated for the first time the effect of lipopolysaccharide and the signal transduction pathway on the biosynthesis of tetrahydrobiopterin [(6R-L-erythro-1',2'-dihydroxypropyl) -2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine], the cofactor for the enzymatic hydroxylation of the aromatic amino acids, in the murine neuroblastoma cell line N1E-115, which synthesizes tetrahydrobiopterin constitutively. " 07/12/1996
- " We examined the release of tetrahydrobiopterin ((6R)-L-erythro-dihydroxypropyl-2-amino-4-hydroxy-5,6,7, 8-tetrahydropteridine; BH4) and nitric oxide induced by lipopolysaccharide from mouse neuroblastoma N1E-115 cells by measuring BH4 and nitric oxide derivatives, nitrites and nitrates, harbored in the conditioned media. "
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2. | Neoplasms (Cancer)
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3. | Mitochondrial Diseases (Mitochondrial Disease)
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4. | Schizophrenia (Dementia Praecox)
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5. | Pheochromocytoma
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