cyclic 3',5'-thymidine monophosphate (cTMP)

09/01/2016 - "RNA interference-mediated depletion of CTMP were finally applied in db/db mice, which restored Akt activity, improved neurological scores and reduced infarct volume. "
01/24/2023 - "Furthermore, post-ischemic CTMP siRNA knockdown led to smaller infarct and better behaviors. "

09/01/2016 - "Inhibitors specifically targeting CTMP may be beneficial in the treatment of cerebral ischemia in patients with diabetes. "
09/01/2016 - "We investigated the role of carboxy-terminal modulator protein (CTMP), an endogenous Akt inhibitor, in brain injury following focal cerebral ischemia in type 2 diabetic db/db mice and their control littermates non-diabetic db/+ mice. "

06/15/2009 - "In this study, we addressed this question by studying the effects of lentivirus-based CTMP in the lungs of 9- and 13-week-old K-ras(LA1) mice, a model of lung cancer. "
05/01/2012 - "Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells."
06/15/2009 - "The effects of CTMP on lung cancer progression and Akt-related signals were evaluated. "
12/01/2007 - "Lentiviral vector-CTMP was delivered into K-ras null lung cancer mice through the nose-only inhalation system for 30 min. After 48 h, the potential effects of CTMP on Akt1-related signals and cell cycle regulation in the lungs were evaluated by western blot, immunohistochemistry and zymography. "
12/01/2007 - "Our results emphasize the importance of noninvasive-targeted delivery of CTMP for lung cancer therapy in the future. "

12/01/2023 - "The present study examined whether sciatic nerve injury (SNI) stimulated CTMP expression in denervated skeletal muscle during muscle atrophy. "
12/01/2023 - "CTMP has also been implicated in promoting muscle degeneration and catabolism in an in vitro muscle atrophy model. "
01/01/2019 - "In conclusion, this is the first study to provide evidence for a link between elevated CTMP expression, downregulated Akt phosphorylation and muscle atrophy in ALS and clearly demonstrates a direct influence of CTMP on Akt phosphorylation in an in vitro muscle cell atrophy model."
12/01/2023 - "Our findings suggest that CTMP is essential to muscle atrophy after denervation and it may act by reducing Akt signaling, protein synthesis, and increasing myocellular catabolism."

10/01/2023 - "With the growing use of comprehensive tumor molecular profiling (CTMP), the therapeutic landscape of cancer is rapidly evolving. "
01/01/2021 - "Bilateral CTMP-based systematic screen further indicates that candidate CTMTs are limited and most notably cancer-type specific. "
01/01/2021 - "As a proof-of-concept, we applied this CTMP computational evaluation on > 10,000 small-molecule compounds using >200,000 Library of Integrated Network-based Cellular Signatures (LINCS) expression profiles generated upon 4 different cancer cell lines. "
06/15/2009 - "Long-term repeated viral delivery of CTMP may provide a useful tool for designing lung tumor treatment."
06/15/2009 - "Long-term repeated delivery of CTMP effectively reduced tumor progression in the lungs at different stages of development. "