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sufoxazine (teniloxazine)
Also Known As:
teniloxazine
; Y 8894; Y-8894
Networked:
6
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Oxazines: 9
Morpholines: 6
sufoxazine: 6
Related Diseases
1.
Amnesia (Dissociative Amnesia)
02/01/1985 - "
Sufoxazine, administered either immediately after CO2 exposure or 30 min prior to the acquisition trial, improved CO2 induced amnesia.
"
02/01/1985 - "
These results suggest that sufoxazine improves amnesia experimentally induced by various methods.
"
02/01/1985 - "
The effects of sufoxazine on various experimental amnesia models were studied using passive avoidance behavior in mice.
"
12/01/1987 - "
The effects of Y-8894 on experimental amnesia in rats induced by transient cerebral ischemia (600 sec) according to the method of Pulsinelli and Brierley were studied using the one trial passive avoidance response and the pole climbing discrete avoidance response.
"
12/01/1987 - "
These results show that Y-8894 has beneficial effects on experimental amnesia induced by transient cerebral ischemia.
"
2.
Ischemia
12/01/1987 - "
3) Y-8894 (5 mg/kg, i.p.) facilitated recovery from the changes in glycolytic metabolism, and inhibited the accumulation of choline due to the dysfunction of the neuronal membranes induced by the ischemia.
"
12/01/1987 - "
The following results were obtained: 1) In the one trial passive avoidance response test, Y-8894 (2.5, 5 and 10 mg/kg, i.p.) improved significantly the decreased latency induced by the ischemia, and it was most effective at 5 mg/kg. Calcium-hopantenate (100, 250 and 500 mg/kg, i.p.) and dihydroergotoxine (5 and 10 mg/kg, i.p.) tended to increase the latency.
"
12/01/1987 - "
On the other hand, physostigmine (0.025, 0.05 and 0.1 mg/kg, i.p.), a cholinesterase inhibitor, increased the latency significantly, and it was most effective at 0.05 mg/kg. 2) The pole climbing discrete avoidance response was significantly decreased by the ischemia compared with the sham operated group, and Y-8894 (5 mg/kg, i.p.) tended to improve this decreased avoidance response.
"
3.
Memory Disorders (Memory Loss)
07/01/1987 - "
The effect of Y-8894 (+/-) 2-[[o-(2-thenyl)phenoxy]methyl] morpholine maleate, which has been shown to improve experimentally induced learning and memory deficits, on cerebral monoamine uptake and turnover was studied in the mouse.
"
4.
Brain Hypoxia (Cerebral Hypoxia)
11/01/1986 - "
In this study, the effect of Y-8894 on the cerebral energy metabolism was investigated using a KCN-induced cerebral anoxia model with mice.
"
10/01/1985 - "
The anti-anoxic effect of sufoxazine was investigated in various cerebral anoxia models with mice, in comparison with those of various cerebroactive drugs.
"
11/01/1986 - "
The present findings suggest that Y-8894 has an ameliorative effect on the cerebral energy metabolic disturbance, and this effect likely plays an important role in the improvement of amnesia and other neurological deficits related to cerebral anoxia.
"
5.
Transient Ischemic Attack
12/01/1987 - "
The effects of Y-8894 on experimental amnesia in rats induced by transient cerebral ischemia (600 sec) according to the method of Pulsinelli and Brierley were studied using the one trial passive avoidance response and the pole climbing discrete avoidance response.
"
12/01/1987 - "
These results show that Y-8894 has beneficial effects on experimental amnesia induced by transient cerebral ischemia.
"
Related Drugs and Biologics
1.
Dihydroergotoxine (Hydrogenated Ergot Alkaloids)
2.
pantogab (hopantenic acid)
3.
morpholine
4.
maleic acid (maleate)
5.
Physostigmine
6.
Cholinesterase Inhibitors (Anticholinesterases)
7.
Choline (Choline Chloride)
8.
salicylhydroxamic acid (SHAM)