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gamma-tert-butyl methotrexate

structure given in first source

Also Known As:

gamma-tBMTX

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Aminopterin: 248
        Methotrexate: 24010
        gamma-tert-butyl methotrexate: 1

Related Diseases

1.	Leukemia L1210 05/01/1985 - "In vivo antitumor activities of gamma-tBAMT and gamma-tBMTX were compared in mice with L1210 leukemia. " 05/01/1985 - "While the activity of gamma-tBAMT was very close to that of gamma-tBMTX in the DHFR inhibition assay, the AMT ester was more potent than the MTX ester against cells in culture and against L1210 leukemia in vivo. "
2.	Leukemia 05/01/1985 - "The inhibitory effects of gamma-tBAMT on the activity of purified dihydrofolate reductase (DHFR) from L1210 murine leukemia cells, the growth of L1210 cells and CEM human leukemic lymphoblasts in suspension culture, and the growth of several lines of human squamous cell carcinoma of the head and neck in monolayer culture were compared with the effects of gamma-tBMTX and the parent acids AMT and methotrexate (MTX). "
3.	Squamous Cell Carcinoma of Head and Neck 05/01/1985 - "The inhibitory effects of gamma-tBAMT on the activity of purified dihydrofolate reductase (DHFR) from L1210 murine leukemia cells, the growth of L1210 cells and CEM human leukemic lymphoblasts in suspension culture, and the growth of several lines of human squamous cell carcinoma of the head and neck in monolayer culture were compared with the effects of gamma-tBMTX and the parent acids AMT and methotrexate (MTX). "

Related Drugs and Biologics

1.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
2.	Suspensions
3.	Methotrexate (Mexate)
4.	Esters
5.	Acids
6.	gamma-tert-butyl aminopterin