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macrophage procoagulant activity
Also Known As:
large granular lymphocyte procoagulant activity; macrophage PCA; macrophage procoagulant inducing factor; procoagulant activity, macrophage
Networked:
35
relevant articles (
1
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Blood Coagulation Factors: 5376
macrophage procoagulant activity: 35
Biological Factors: 2472
Blood Coagulation Factors: 5376
macrophage procoagulant activity: 35
Related Diseases
1.
Thrombosis (Thrombus)
10/01/1989 - "
Augmented macrophage PCA may contribute to thrombus formation on ulcerated plaques.
"
06/01/1986 - "
We conclude that prolongation of skin allograft survival by CsA is related to its ability to prevent cell mediated injury to the endothelium of graft vessels, and possibly also to inhibition of macrophage PCA with consequent reduced thrombus formation.
"
11/01/1998 - "
Preservation of extravascular hemostasis was further demonstrated in activated factor IX-treated animals by (1) significantly increased levels of thrombin-antithrombin III complex and prothrombin activation peptide (F1+2) without intravascular thrombosis, (2) significantly greater macrophage procoagulant activity in pericardial-derived monocytes, and (3) immunohistochemical evidence of tissue factor expression in pericardial mesothelial cells and macrophages.
"
2.
Infections
01/01/1998 - "
These studies were designed to examine the influence of Th1/Th2 cells on resistance/susceptibility and production of macrophage procoagulant activity (PCA) in resistant (A/J) and susceptible (Balb/cJ) strains of mice following infection with MHV-3.
"
05/01/1996 - "
These studies were designed to examine the influence of Th1/Th2 cells on resistance/susceptibility and production of macrophage PCA in resistant (A/J) and susceptible (BALB/cJ) strains of mice following infection with MHV-3.
"
01/01/1998 - "
These results demonstrate that susceptible Balb/cJ mice generate a Th2 response following MHV-3 infection and that these Th2 cells neither inhibit MHV-3-induced macrophage PCA production nor protect naive mice from MHV-3 infection.
"
05/01/1996 - "
These results demonstrate that susceptible BALB/cJ mice generate a Th2 response following MHV-3 infection and that these Th2 cells neither inhibit MHV-3-induced macrophage PCA production nor protect naive mice from MHV-3 infection.
"
05/01/1996 - "
Transfer of spleen cells and T cell lines from immunized BALB/cJ mice failed to protect naive susceptible syngeneic mice from infection with MHV-3 and augmented macrophage PCA production to MHV-3 in vitro.
"
3.
Disease Progression
10/01/1992 - "
In the present study, we examined the immunosuppressive effects of 16,16 dimethyl prostaglandin E2 (dmPGE2) alone and in combination therapy with low-dose CsA to assess the clinical course, histology and expression of monocyte/macrophage procoagulant activity (PCA) following small intestinal transplantation in a heterotopic model of rat allograft rejection.
"
4.
Necrosis
01/01/1998 - "
The development of liver necrosis has been shown to be related to production of a unique macrophage procoagulant activity (PCA), encoded by the gene fgl-2, in susceptible mice.
"
05/01/1996 - "
The development of liver necrosis has been shown to be related to production of a unique macrophage procoagulant activity (PCA), encoded by the gene fgl-2, in susceptible mice.
"
05/01/1995 - "
The induction of macrophage procoagulant activity (PCA) has been shown to correlate with the development of fulminant hepatic necrosis after infection with murine hepatitis virus strain 3 (MHV-3).
"
04/01/1987 - "
Macrophage procoagulant inducing factor (MPIF), a soluble product of stimulated TDTH lymphocytes, may act together with two monokines, interleukin 1 and tumour necrosis factor alpha, which induce thromboplastin on endothelial cells, to initiate the fibrin deposition which is a common feature of many diseases in which CMI plays a role.
"
5.
Abscess
09/01/1996 - "
Macrophage procoagulant activity (PCA) has been proposed as a key mediator of abscess formation.
"
09/01/1996 - "
Cellular mechanisms of abscess formation: macrophage procoagulant activity and major histocompatibility complex recognition.
"
09/01/1995 - "
The three Gram-negative bacilli tested significantly upregulated both abscess formation and macrophage procoagulant activity, with a strong linear correlation between abscess formation and procoagulant activity.
"
01/01/1995 - "
These results support the hypothesis that macrophage PCA produced locally is critical for intraperitoneal abscess formation.
"
09/01/1995 - "
In the case of peritonitis and intraperitoneal abscess formation, these changes may be mediated by the upregulation of macrophage procoagulant activity.
"
Related Drugs and Biologics
1.
Thromboplastin (Tissue Factor)
2.
Peptides (Polypeptides)
3.
Factor IXa (Coagulation Factor IXa)
4.
Prothrombin (Factor II)
5.
antithrombin III-protease complex
6.
Dinoprostone (PGE2)
7.
Monoclonal Antibodies
8.
Fibrin
9.
Endotoxins
10.
Monokines
Related Therapies and Procedures
1.
Transplantation
2.
Therapeutics
3.
Aftercare (After-Treatment)