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benazepril (Briem)

structure given in first source

Also Known As:

Briem; Lotensin; Beecham brand of benazepril hydrochloride; CGS-14824-A; CGS-14824A; Cibacen; Cibacène; Labopal; Novartis brand of benazepril hydrochloride; Pierre Fabre brand of benazepril hydrochloride; benazapril; benazepril hydrochloride; benzazepril; 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-

Networked: 278 relevant articles (57 outcomes, 95 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Benzazepines: 5
    - benazepril: 278

Experts

1.	Weber, Michael A: 10 articles (07/2013 - 09/2004)
2.	Pitt, Bertram: 10 articles (07/2013 - 09/2004)
3.	Bakris, George L: 10 articles (02/2013 - 01/2002)
4.	Velazquez, Eric J: 7 articles (02/2013 - 09/2004)
5.	Jamerson, Kenneth: 6 articles (03/2014 - 12/2008)
6.	Hester, Allen: 6 articles (07/2013 - 01/2008)
7.	Kelly, Roxzana Y: 6 articles (07/2013 - 04/2010)
8.	Dahlöf, Björn: 6 articles (04/2012 - 09/2004)
9.	Weir, Matthew R: 5 articles (02/2013 - 06/2002)
10.	Jamerson, Kenneth A: 5 articles (04/2012 - 06/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 03/01/2001 - "Administration of benazepril was also associated with a small but significant reduction in degree of systemic hypertension and an increase in whole kidney GFR. " 03/01/1994 - "The aim of the study was to evaluate efficacy of benazepril prescribed as replacement therapy in patients with mild to moderate hypertension, according to the pharmacological class of the previous unsuccessful drug. " 01/01/1998 - "[Antihypertensive action and predictive factors of efficacy of benazepril in mild-to-moderate hypertension: clinical trial in general medical practice on 16,987 patients]." 09/08/1996 - "[Efficacy of benazepril monotherapy in moderate essential hypertension studied by automatic ambulatory blood pressure monitoring]." 12/01/2010 - "Furthermore, the recent Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial showed decreased cardiovascular morbidity and mortality with benazepril when administered as a cotreatment. "
2.	Heart Failure 10/14/2014 - "[Effect of benazepril on cardiac function in Chinese patients with chronic heart failure: a meta-analysis of randomized controlled trials]." 05/01/1999 - "The mean survival time (to death or withdrawal from the study due to worsening of heart failure) was 2.7 times longer in the benazepril treated group (428 days) as compared with the placebo group (158 days). " 02/01/1993 - "The purpose of this study was to examine the sequential changes in renal and cardiovascular function produced by chronic Benazepril administration at different stages of heart failure in dogs. " 12/01/1990 - "Previous studies have shown benazepril to lower blood pressure in hypertensive patients and to confer acute hemodynamic benefits in patients with congestive heart failure (CHF). " 12/01/1990 - "In this study, 21 patients with New York Heart Association Class III or IV congestive heart failure were treated with 2 to 15 mg of benazepril HCl as a single daily oral dose for 28 days to determine the clinical and hemodynamic value of chronic therapy. "
3.	Proteinuria 01/01/1993 - "In conclusion, the results of this study suggest that proteinuria in the nephrotic range does not require a change in benazepril dosage." 01/01/2014 - "Administration of a RD to PNAz dogs treated with benazepril (Be) improves proteinuria control compared with the administration of a maintenance diet (MD). " 01/01/2014 - "Evaluation of the effects of a therapeutic renal diet to control proteinuria in proteinuric non-azotemic dogs treated with benazepril." 02/15/2012 - "Chinese medicine integrated with benazepril can ameliorate renal function and decrease proteinuria synergistically." 02/15/2012 - "Benazepril significantly decreased the proteinuria. "
4.	Renal Insufficiency (Renal Failure) 01/01/1999 - "A multicenter European study was designed to determine whether the ACE inhibitor benazepril was safe and effective in protecting residual renal function in patients with various renal diseases and mild to moderate renal failure. " 04/11/1996 - "Benazepril provides protection against the progression of renal insufficiency in patients with various renal diseases." 07/01/2011 - "The purpose of this study was to assess the influence of benazepril administration on the development of CI-AKI in patients with mild to moderate renal insufficiency undergoing coronary intervention. " 01/01/2008 - "Chinese prospective clinical trials showed that benazepril (BZ) conferred substantial renal benefits in patients with advanced renal insufficiency. " 10/01/1996 - "In AIPRI trial (ACE-inhibition in the progression of renal insufficiency) the ACE-inhibitor benazepril was able to protect patients with mild-to-moderate renal disease against the progression of renal insufficiency. "
5.	Fibrosis (Cirrhosis) 03/01/2002 - "Combination therapy with benazepril and oral adsorbent ameliorates progressive renal fibrosis in uremic rats." 01/20/2009 - "The present study was to disclose the effect of MMF combined with benazapril on delaying tubulointerstitial fibrosis and its possible mechanisms in 5/6 nephrectomized rats. " 08/01/2010 - "Effects of benazepril on cardiac fibrosis in STZ-induced diabetic rats." 04/01/1997 - "Benazepril slowed the tubulointerstitial fibrosis (TIF) and reduced the expression of AT1A in the renal tubular epithelial cells, the interstitial areas, and the walls of renal arteriole in the UUO-T group. " 12/01/1990 - "Thus, there seems to be no need for dosage adjustment of benazepril hydrochloride in patients suffering from cirrhosis of the liver."

Related Drugs and Biologics

1.	Amlodipine (Norvasc)
2.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
3.	Hydrochlorothiazide (Esidrix)
4.	valsartan (Vals)
5.	Creatinine
6.	Losartan (Cozaar)
7.	Angiotensin II
8.	Captopril (Capoten)
9.	Calcium Channels (Calcium Channel)
10.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Ligation
3.	Nephrectomy
4.	Angioplasty (Angioplasty, Transluminal)
5.	Surgical Instruments (Clip)