gracillin

01/01/2022 - "Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway."
06/01/2003 - "Gracillin was cytotoxic against most cell lines with GI(50), TGI and LC(50) at micromolar levels, but no activity against EKVX (non-small cell lung cancer), HT29 (colon cancer), OVCAR-5 (ovarian cancer), and SN12C (renal cancer). "

01/01/2021 - "Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway."

09/01/2018 - "Topical co-treatment of gracillin and DNCB for two weeks markedly reduced symptoms typical of AD (redness, itching, swelling and skin lichenification), decreased transepidermal water loss (TEWL) and increased skin hydration. "

01/01/2023 - "In vivo studies showed that gracillin (1 mg/kg or 8 mg/kg, administered intraperitoneally for 16 consecutive days) suppressed B16F10 tumor growth and Src/STAT3 and AKT/mTOR signaling in tumors. "
01/01/2021 - "These results of the present study are an important step toward the medicinal development of gracillin, and are also of use in understanding the effect of TIPE2 as a potential tumor target."
09/01/2023 - "The findings demonstrated that gracillin displays promising anticancer effects through various molecular mechanisms, including anti-inflammatory effects, apoptotic cell death, induction of oxidative stress, cytotoxicity, induction of genotoxicity, cell cycle arrest, anti-proliferative effect, autophagy, inhibition of glycolysis, and blocking of cancer cell migration. "
09/01/2023 - "This review was designated to summarize the research progress on the anti-cancer activities of gracillin focusing on the underlying cellular and molecular mechanisms, as well as its pharmacokinetic features. "
01/01/2022 - "At last, the anti-tumor growth activity of gracillin in vivo was validated in A549-bearing athymic nude mice. "

11/15/2023 - "This study aims to elucidate and verify the anti-pulmonary fibrosis effect of gracillin. "
11/15/2023 - "Gracillin relieves pulmonary fibrosis by suppressing the STAT3 axis."