MACOP-B protocol

chemotherapy protocol consisting of above cpds; used in treatment of large cell and immunoblastic lymphomas

Also Known As:

MECOP-B PROTOCOL; TTL-I protocol

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACOP-B protocol: 4
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACOP-B protocol: 4
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACOP-B protocol: 4
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        MACOP-B protocol: 4
- Glycoconjugates: 1353
  - Glycopeptides: 1928
    - Bleomycin: 9833
      - MACOP-B protocol: 4
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Glycopeptides: 1928
    - Bleomycin: 9833
      - MACOP-B protocol: 4
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        Vincristine: 9251
        MACOP-B protocol: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Tetrahydrofolates: 8
    - Formyltetrahydrofolates
      - Leucovorin: 5743
        MACOP-B protocol: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        Doxorubicin: 35390
        MACOP-B protocol: 4
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        Phosphoramide Mustards: 5
        Cyclophosphamide: 25473
        MACOP-B protocol: 4
- Organophosphorus Compounds: 300
  - Phosphoramides: 8
    - Phosphoramide Mustards: 5
      - Cyclophosphamide: 25473
        MACOP-B protocol: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        MACOP-B protocol: 4
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienediols
        Prednisone: 12650
        MACOP-B protocol: 4

Related Diseases

1.	Lymphoma (Lymphomas) 01/01/1992 - "Intensive combination chemotherapy (TTL-I protocol) of large cell and immunoblastic lymphomas--long-term observation." 10/26/1991 - "[The treatment of large-cell non-Hodgkin's lymphomas with the MACOP-B protocol]." 02/01/1995 - "Intensive treatment of AIDS-related non-Hodgkin's lymphomas with the MACOP-B protocol."
2.	Non-Hodgkin Lymphoma (Lymphosarcoma) 02/01/1995 - "The usefulness of intensive chemotherapy with the MACOP-B protocol was evaluated in 8 patients with AIDS-related non-Hodgkin's lymphoma (NHL). " 11/09/1990 - "Four out of eleven patients--none of them HIV positive--who received treatment for non-Hodgkin lymphoma by the MACOP-B protocol between June 1989 and February 1990 were taken ill during or shortly after the conclusion of the course with fulminant pneumonia necessitating artificial ventilation. "
3.	Mucositis 10/26/1991 - "The toxicity of the MACOP-B protocol was high: mucositis (65%), cytopenia (55%), neuropathy (40%), complications of steroid therapy (15%), and mortality directly related with therapy in 15%. "
4.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 11/09/1990 - "[Acute pneumocystosis during polychemotherapy following the MACOP-B protocol]."
5.	Pneumonia (Pneumonitis) 11/09/1990 - "Four out of eleven patients--none of them HIV positive--who received treatment for non-Hodgkin lymphoma by the MACOP-B protocol between June 1989 and February 1990 were taken ill during or shortly after the conclusion of the course with fulminant pneumonia necessitating artificial ventilation. "

Related Drugs and Biologics

1.	Steroids

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)