neurofilament protein L

amino acid sequence given in first source; different from neurofilament proteins M & H; RefSeq NM_006158 (human), NM_010910 (mouse)

Also Known As:

CMT1F protein, human; CMT2E protein, human; CMT2E protein, mouse; NEFL polypeptide; NEFL protein; NEFL protein, human; NF-L polypeptide; NF-L protein; NF68 protein, human; NF68 protein, mouse; NFL protein, mouse; Nefl protein, mouse; Neurofilament triplet L protein, human; light neurofilament protein; neurofilament light polypeptide; neurofilament protein light; neurofilament, light polypeptide 68kDa protein, human; neurofilament, light polypeptide, mouse

Networked: 40 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Ju: 3 articles (02/2016 - 03/2012)
2.	Lin, Hong: 3 articles (12/2007 - 03/2004)
3.	Schlaepfer, William W: 3 articles (12/2007 - 03/2004)
4.	Zhai, Jinbin: 3 articles (12/2007 - 03/2004)
5.	Brown, Anthony: 2 articles (01/2021 - 01/2019)
6.	Stone, Elizabeth J: 2 articles (01/2021 - 01/2019)
7.	Brown, Kristy: 2 articles (01/2017 - 04/2015)
8.	Liem, Ronald K H: 2 articles (01/2017 - 04/2015)
9.	Zhao, Jian: 2 articles (01/2017 - 04/2015)
10.	Chen, Baishen: 2 articles (02/2016 - 03/2012)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2019 - "Collectively, our study demonstrated that miR-7a ameliorated neuropathic pain via blocking the signal transducer and activator of transcription signaling pathway by repressing neurofilament light polypeptide. " 01/01/2019 - "Furthermore, the regulatory effect of neurofilament light polypeptide on neuropathic pain was detected using plasmid overexpressing neurofilament light polypeptide. " 01/01/2019 - "MicroRNA-7a ameliorates neuropathic pain in a rat model of spinal nerve ligation via the neurofilament light polypeptide-dependent signal transducer and activator of transcription signaling pathway."
2.	Neoplasms (Cancer) 03/01/2014 - "Although evidence suggests that there is a correlation between NEFL expression and cancer, studies regarding the role of the NEFL protein have been mostly limited to neurological diseases, such as Charcot-Marie-Tooth's disease (CMT). " 03/01/2014 - "However, the role of the NEFL protein has not yet been studied in cancer cells. " 03/01/2014 - "The neurofilament light polypeptide (NEFL) gene located on chromosome 8q21 is associated with the cancer of several organs and is regarded as a potential tumor suppressor gene. " 11/01/2010 - "However, there was a significant overexpression of neuronal markers in SE compared with IE: neurofilament light polypeptide 70 (NEFL)-positive tumor cells were found in 23 of 34 SE and in only 4 of 32 IE (P < .001). " 01/01/2012 - "Neurofilament, light polypeptide (NEFL) was demonstrated to be ectopically expressed in breast cancer tissues and decreased in lymph node metastases compared to the paired primary breast cancers in our previous study. "
3.	Ocular Hypertension (Glaucoma, Suspect) 07/09/2004 - "The purpose of this study is to evaluate the changes in neurofilament light (NF-L) protein in the optic nerve in rat kainate and monkey ocular hypertension models. "
4.	Nervous System Diseases (Neurological Disorders) 12/01/2007 - "We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 40 age- and sex-matched healthy controls to test the hypothesis that cerebrospinal fluid (CSF) levels of neurofilament light (NF-L) protein, a marker of axonal degeneration, might provide diagnostic and prognostic information on the disease. "
5.	Lymphatic Metastasis 01/01/2012 - "Neurofilament, light polypeptide (NEFL) was demonstrated to be ectopically expressed in breast cancer tissues and decreased in lymph node metastases compared to the paired primary breast cancers in our previous study. "

Related Drugs and Biologics

1.	Kainic Acid (Kainate)
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	Antigens
5.	N-Methylaspartate (NMDA)
6.	Retinaldehyde (Retinal)
7.	Biomarkers (Surrogate Marker)
8.	Serum Albumin
9.	Phosphopyruvate Hydratase (Enolase)
10.	Immunosorbents

Related Therapies and Procedures

1.	Ligation
2.	Intraocular Injections
3.	Axotomy