6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)

04/14/2000 - "We have determined the three-dimensional structure of 6, 7-dimethyl-8-ribityllumazine synthase (lumazine synthase) from Brucella abortus, the infectious organism of the disease brucellosis in animals. "
01/01/2019 - "Production of Brucella lumazine Synthase Recombinant Protein to Design a Subunit Vaccine against Undulant Fever."
09/24/2002 - "In the present study three ELISA tests using lipopolysaccharide (LPS)-free cytoplasmic proteins (CPs) of Brucella abortus, the lumazine synthase (LS) of Brucella spp. or a hot-saline (HS) extract of Brucella canis containing outer membrane antigens were used to test sera from dogs with suspected or confirmed brucellosis (n=36) and from dogs with pathological conditions other than brucellosis (n=212). "
09/30/2018 - "This study explores the efficacy of a Salmonella Typhimurium delivery-based combination vaccine for four heterologous Brucella antigens (Brucella lumazine synthase, proline racemase subunit A, outer-membrane protein 19, and Cu/Zn superoxide dismutase) targeting brucellosis in goats. "

10/01/2006 - "tuberculosis lumazine synthase in complex with five different inhibitor compounds is presented, together with studies of the binding reactions by isothermal titration calorimetry. "
05/15/2010 - "tuberculosis lumazine synthase with a K(i) of 70microM. "
08/07/2009 - "tuberculosis lumazine synthase."
09/14/2007 - "tuberculosis lumazine synthase (Ki 31 microM), E. "
03/01/2005 - "To develop potent antibiotics for the treatment of tuberculosis, we have determined the structure of lumazine synthase from M. "

01/21/2013 - "Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice."
10/19/2022 - "This study aimed to investigate the protective effect of mini-hemagglutinin (mini-HA) proteins expressed on lumazine synthase (LS) nanoparticles against influenza. "

04/01/2006 - "Brucella lumazine synthase (BLS) has been previously used with success as a delivery system for systemic immunization against murine cysticercosis. "
04/15/2005 - "Lumazine synthase from Brucella spp. (BLS) was evaluated as a protein carrier to improve antigen delivery of KETc1, one of the peptides of the anti-cysticercosis vaccine. "

03/23/2021 - "The results showed that the Gn head domain, when bound to the lumazine synthase-based MPSP, reduced mortality in a lethal mouse model and protected lambs, the most susceptible RVFV target animals, from viremia and clinical signs after immunization. "