etonogestrel (Implanon)

metabolite of DESOGESTREL; structure given in first source; Implanon: implant containing etonogestrel (3-keto-desogestrel)

Also Known As:

Implanon; 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one; 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-; 3-keto-desogestrel; 3-ketodesogestrel; 3-oxo desogestrel; 3-oxodesogestrel; ORG-3236; nexplanon

Networked: 214 relevant articles (17 outcomes, 40 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Norsteroids: 16
      - Norpregnanes: 2
        Norpregnenes
        Desogestrel: 311
        etonogestrel: 214

Experts

1.	Bahamondes, Luis: 9 articles (01/2022 - 05/2006)
2.	Sheeder, Jeanelle: 8 articles (01/2022 - 09/2015)
3.	Teal, Stephanie: 6 articles (01/2022 - 02/2014)
4.	Fraser, Ian S: 6 articles (10/2019 - 06/2007)
5.	Lazorwitz, Aaron: 4 articles (01/2022 - 10/2019)
6.	Creinin, Mitchell D: 4 articles (10/2019 - 12/2007)
7.	Aquilante, Christina L: 3 articles (01/2021 - 10/2019)
8.	Margatho, Deborah: 3 articles (04/2020 - 10/2018)
9.	Korver, Tjeerd: 3 articles (10/2019 - 06/2008)
10.	Mansour, Diana: 3 articles (10/2019 - 06/2008)

Related Diseases

1.	Endometriosis 06/01/2020 - "This study aimed to investigate the efficacy of the etonogestrel (ENG)-releasing implant in treating patients with rectovaginal endometriosis. " 10/01/2005 - "To evaluate the efficacy of Implanon on treatment of symptomatic endometriosis An open clinical study without control group Family Planning Clinic and out patient department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. " 10/01/2005 - "Implanon, a sub-dermalprogestin implant is an effective hormonal alternative for treatment of symptomatic endometriosis. " 10/01/2005 - "The effects of implanon in the symptomatic treatment of endometriosis." 01/01/2005 - "Etonogestrel subdermal implants are an additional treatment option in women with symptoms related to pelvic endometriosis."
2.	Dysmenorrhea (Menstrual Pain) 01/01/2009 - "Implanon has been reported to be effective in the treatment of dysmenorrhea. " 04/01/2019 - "A 16-year-old female patient with history of depression, sexual abuse, and dysmenorrhea insistently requested etonogestrel rod removal. " 09/15/2010 - "Implanon, the single-rod implantable contraceptive device, may reduce symptoms of dysmenorrhea. " 12/01/1998 - "Dysmenorrhea clearly improved during use of both Implanon and Norplant. " 09/01/2018 - "RESULTS All 17 patients treated with etonogestrel implants completed the 12-month follow-up, at which time, the mean hemoglobin level (127.08±2.56 g/L) was significantly higher compared with that at baseline (94.54±5.47 g/L; P<0.01); uterine volume, serum CA125, and VAS score for dysmenorrhea at 12 months (118.03±12.83 cm³, 34.58±9.66 U/mL, and 1.45±0.35, respectively) were significantly lower when compared with baseline (198.53±39.47 cm³, 100.41±49.89 U/mL, and 7.62±0.74, respectively) (P<0.01, for all). "
3.	Pelvic Pain 10/01/2023 - "Editorial Expression of Concern: The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study." 09/01/2009 - "The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study." 02/12/2021 - " four patients who were treated with Etonogestrel implants completed the 24-month follow-up in which we found a significant decrease in pelvic pain VAS scores comparing baseline scores to 6, 12, and 24 months (baseline: 6.39 ± 2.35 to 24-month: 0.17 ± 0.69, P < 0.05). " 09/01/2009 - "Implanon seems to be an effective hormonal alternative for long-term treatment of properly selected patients with pure PCS-related pelvic pain." 09/01/2009 - "To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). "
4.	Hemorrhage 08/01/2009 - "We compared four treatments against a placebo in Implanon users and tested whether repeated treatment improved subsequent bleeding patterns. " 09/01/2010 - "The study was conducted to evaluate the bleeding pattern, efficacy and discontinuation rate of etonogestrel implant (68 mg) inserted in postpartum adolescents. " 01/01/2006 - "The aim of this study was to compare three treatments with placebo on the duration and recurrence of frequent and/or prolonged bleeding in Implanon users. " 12/01/2021 - "The Etonogestrel Implant in Adolescents: Factors Associated With Removal for Bothersome Bleeding in the First Year After Insertion." 02/01/2021 - "A third of women chose not to reinsert Implanon NXT after three years due to side effects such as problematic bleeding. "
5.	Pain (Aches) 09/01/2000 - "Implanon is easy to insert and remove with minimal complications and pain. " 07/01/2006 - "However, injury to branches of the medial antebrachial cutaneous nerve during Implanon insertion and removal can result in impaired sensibility, severe localized pain, or the formation of painful neuroma that can be quite devastating to the patient. " 01/01/2009 - "After 6 months, the average decrease in pain was 68% in the Implanon group and 53% in the DMPA group. " 04/01/2020 - "Objectives: The aims of the study were to correlate endometriosis-associated pain, evaluated by visual analogue scale (VAS) scores, with serum levels of etonogestrel (ENG), levonorgestrel (LNG), CA-125 and soluble CD23 in users of the ENG implant or the 52-mg LNG-releasing intrauterine system (52 mg LNG-IUS) for up to 2 years after device placement.Methods" 03/01/2022 - "Etonogestrel- and segesterone-releasing progestin subdermal implants appear to improve endometriosis-related pain symptoms and quality of life and may provide an additional component in the management of endometriosis. "

Related Drugs and Biologics

1.	Levonorgestrel (Plan B)
2.	Progestins (Progestagens)
3.	Contraceptive Agents (Contraceptives)
4.	Mifepristone (RU 486)
5.	Doxycycline (Periostat)
6.	Ethinyl Estradiol (Estinyl)
7.	Combined Oral Contraceptives
8.	Antigens
9.	N,N-dimethyl-4-anisidine (DMPA)
10.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Aftercare (After-Treatment)
3.	Female Contraceptive Devices (Vaginal Ring)
4.	Therapeutics
5.	Intrauterine Devices (Intrauterine Device)