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N- (2- aminoethyl)- 5- isoquinolinesulfonamide (H-9)

Also Known As:

H-9; AEIQS; protein kinase C inhibitor H-9

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - N-(2-aminoethyl)-5-isoquinolinesulfonamide: 10
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - N-(2-aminoethyl)-5-isoquinolinesulfonamide: 10
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - N-(2-aminoethyl)-5-isoquinolinesulfonamide: 10

Experts

1.	Cao, X: 1 article (05/2012)
2.	Chen, H-F: 1 article (05/2012)
3.	Chen, J: 1 article (05/2012)
4.	Chen, L: 1 article (05/2012)
5.	Dai, Y: 1 article (05/2012)
6.	Hu, Q-Y: 1 article (05/2012)
7.	Jiang, F: 1 article (05/2012)
8.	Jiang, M-M: 1 article (05/2012)
9.	Liu, J: 1 article (05/2012)
10.	Qin, B: 1 article (05/2012)

Related Diseases

1.	Seizures (Absence Seizure) 05/01/2005 - "No significant modifications were found in PKA activity during seizures as compared to control rats, but H-9 dihydrochloride microperfusion (100 microM) prevented picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration. " 05/01/2005 - "In this study, we determined PKA enzymatic activity in the rat hippocampus during picrotoxin-induced seizures, using H-9 dihydrochloride, a PKA inhibitor, to investigate the in vivo effects of this enzyme on seizures induced by picrotoxin microdialysis in the rat hippocampus. "
2.	Infections 07/01/1991 - "Global analysis of lymphocyte gene expression: perturbation of H-9 cells by infection with distinct isolates of human immunodeficiency virus--an exposition by multivariate analysis of a host-parasite interface." 02/01/1986 - "These samples were used for cocultivation of LAV/HTLV-III. This resulted in inducing in MT-2 cells a cytopathic effect characteristic for LAV/HTLV-III infections, induced by thymus, spleen, lungs and brain tissue of the foetus after cocultivation with umbilical cord lymphocytes; in H-9 and MT-2 cells this led to the expression and release of antigens reacting with LAV/HTLV-III-specific anti-bodies. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/05/1993 - "Two cis stereoisomers of 2',3'-dideoxy-3'-thiacytidine (SddC) were investigated for their activity against human immunodeficiency virus type 1 (HIV-1) in human acute lymphoblastic leukemia H-9 cells. "
4.	Virus Diseases (Viral Diseases) 12/01/1988 - "Pretreatment of H-9 cells and human lymphocytes with CyA over 24 hours completely prevented viral infection over a 21-day period, whereas the addition of drug at two hours postinfection with HIV-1 had a significant inhibitory effect on viral replication and expression of the virus-specific antigens p17 and p24. "
5.	Vaccinia 09/01/1986 - "Effects of treating H-9 rat myoblasts with alpha-amanitin upon vaccinia-specific protein synthesis were also examined. "

Related Drugs and Biologics

1.	Picrotoxin
2.	Enzymes
3.	protein kinase modulator
4.	Proteins (Proteins, Gene)
5.	Antigens
6.	Alpha-Amanitin
7.	Catenins
8.	Staurosporine
9.	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
10.	Lamivudine (Epivir)