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N-acetylglutamate 4-nitroanilide (AGNA)

RN given refers to (R)-isomer

Also Known As:

AGNA; AcGlu-pNA; N-acetylglutamate 4-nitroanilide, (S)-isomer

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - N-acetylglutamate 4-nitroanilide: 6
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - N-acetylglutamate 4-nitroanilide: 6

Experts

1.	Graus, F: 2 articles (03/2008 - 08/2005)
2.	Sabater, L: 2 articles (03/2008 - 08/2005)
3.	Saiz, A: 2 articles (03/2008 - 08/2005)
4.	Coniglio, S: 1 article (06/2022)
5.	Giovannini, G: 1 article (06/2022)
6.	Mazzoli, M: 1 article (06/2022)
7.	Meletti, S: 1 article (06/2022)
8.	Turchi, G: 1 article (06/2022)
9.	Vaudano, Anna Elisabetta: 1 article (06/2022)
10.	Deuschl, Cornelius: 1 article (05/2021)

Related Diseases

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/2017 - "We report a patient with AGNA-positive LE who is later diagnosed and treated for small-cell lung carcinoma." 08/01/2005 - "We describe a new antibody, called anti-glial nuclear antibody (AGNA), in patients with paraneoplastic neurological syndromes (PNS) and small-cell lung carcinoma (SCLC). " 03/18/2008 - "We reported that 43% of patients with Lambert-Eaton myasthenic syndrome (LEMS) and small cell lung cancer (SCLC) had an antibody called anti-glial nuclear antibody (AGNA), defined by the immunoreaction with the nuclei of the Bergmann glia of the cerebellum. " 06/01/2022 - "Antibodies against SOX1 (or anti-glial nuclear antibody, AGNA) are partially characterized onconeural antibodies, firstly described in association with small cell lung cancer (SCLC). "
2.	Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome) 03/18/2008 - "We reported that 43% of patients with Lambert-Eaton myasthenic syndrome (LEMS) and small cell lung cancer (SCLC) had an antibody called anti-glial nuclear antibody (AGNA), defined by the immunoreaction with the nuclei of the Bergmann glia of the cerebellum. " 05/24/2021 - "Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies."
3.	Paraneoplastic Cerebellar Degeneration 05/24/2021 - "Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies."
4.	Polyneuropathies (Polyneuropathy) 05/24/2021 - "Herein, we present a SCLC patient with rapidly progressive PCD, LEMS and axonal polyneuropathy associated with AGNA/SOX1-antibodies, successfully treated with plasma-exchange (PLEX)."
5.	Neoplasms (Cancer) 08/01/2005 - "AGNA was present in 13/30 (43%) of LEMS patients with SCLC, compared with 0/19 of LEMS patients without cancer (p=0.0006). " 08/01/2005 - "AGNA was identified in 13/113 (11.5%) patients with SCLC compared with 0/122 with other types of cancer (p<0.0001). "

Related Drugs and Biologics

1.	Antibodies
2.	Myelin-Oligodendrocyte Glycoprotein
3.	Semaphorin-3A
4.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
5.	GABA Receptors (GABA Receptor)
6.	Glutamate Receptors (Glutamate Receptor)
7.	N-Methylaspartate (NMDA)
8.	Proteins (Proteins, Gene)
9.	Protein Kinases (Protein Kinase)
10.	Leucine (L-Leucine)

Related Therapies and Procedures

1.	Plasma Exchange