preprotachykinin

beta-preprotachykinin contains both substance P & substance K sequence; alpha-preprotachykinin contains substance P sequence only; gamma-preprotachykinin contains the sequence of both substance P and neurokinin A; delta-preprotachy kinin contains the sequence of substance P but not neurokinin A; RefSeq NM_009312 (mouse)

Also Known As:

Networked: 81 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bhatia, Madhav: 12 articles (11/2010 - 05/2003)
2.	Hegde, Akhil: 6 articles (05/2010 - 03/2006)
3.	Moochhala, Shabbir M: 5 articles (05/2010 - 03/2006)
4.	Lu, Jia: 4 articles (11/2010 - 03/2006)
5.	Zhang, Huili: 4 articles (02/2008 - 11/2006)
6.	Moochhala, Shabbir: 3 articles (11/2010 - 06/2008)
7.	Ng, Siaw Wei: 3 articles (02/2008 - 03/2006)
8.	Rameshwar, Pranela: 3 articles (01/2005 - 04/2004)
9.	Dubois, Dave: 2 articles (09/2011 - 12/2010)
10.	Gendron, Louis: 2 articles (09/2011 - 12/2010)

Related Diseases

1.	Experimental Diabetes Mellitus 12/01/1996 - "After 24 weeks of streptozotocin-diabetes, there was a non-significant reduction in gamma-preprotachykinin mRNA expression whilst substance P levels in dorsal root ganglia, sciatic nerve and synovium and nerve growth factor levels in the sciatic nerve were significantly decreased. "
2.	Inflammation 10/01/2004 - "Expression of spinal SP and the preprotachykinin-A (PPT-A) gene that encodes SP exhibits plasticity in response to conditions such as peripheral inflammation but the mechanisms that regulate expression are poorly understood. " 12/01/2010 - "Therefore, we investigated the role of SP in DOPR-mediated analgesia by using preprotachykinin A (precursor of SP) knockout mice (PPTA(-/-) ) in the CFA model of inflammation. " 11/27/1995 - "The effect of a unilateral inflammation at the rat's ankle joint on the expression of preprotachykinin-A mRNA and preprosomatostatin mRNA in dorsal root ganglion cells--a study using non-radioactive in situ hybridization." 04/01/2001 - "Adjuvant-induced joint inflammation causes very rapid transcription of beta-preprotachykinin and alpha-CGRP genes in innervating sensory ganglia." 12/01/1996 - "Twenty-four hours after induction of inflammation in non-diabetic rats, gamma-preprotachykinin mRNA expression was increased in the L4/L5 dorsal root ganglia. "
3.	Sepsis (Septicemia) 01/01/2010 - "Plasma cytokine profiles in preprotachykinin-A knockout mice subjected to polymicrobial sepsis." 09/15/2007 - "Male Swiss mice or male preprotachykinin-A gene knockout (PPT-A-/-) mice and their wild-type (PPT-A+/+) mice were subjected to CLP-induced sepsis. " 09/01/2007 - "In that study, mice lacking the preprotachykinin-A gene, which encodes for SP, were protected against lung injury in sepsis. " 03/15/2006 - "Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis." 01/01/2010 - "We herein investigated the circulating cytokine profiles in preprotachykinin-A knockout (PPTA(-/-)) mice, which have been found to be protected significantly against microbial sepsis, by employing multiplexed bead-based suspension arrays for the measurement of 18 plasma cytokines. "
4.	Lung Injury 09/01/2007 - "In that study, mice lacking the preprotachykinin-A gene, which encodes for SP, were protected against lung injury in sepsis. " 03/15/2006 - "Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis." 05/01/2003 - "Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury." 05/01/2010 - "Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A-/- mice." 05/01/2010 - "Deletion of mouse preprotachykinin-A (PPTA), which encodes mainly for neuropeptide substance P, has been shown to protect against lung injury and mortality in sepsis. "
5.	Granuloma 12/01/2008 - "In the current studies, we determined whether absence of SP/SP receptor circuitry in the SP-precursor, preprotachykinin, knockout or SP-receptor, neurokinin (NK) 1, knockout mice affected granuloma cytokine production. " 04/01/2005 - "SP mRNA (preprotachykinin A (PPT A)) was detected within the schistosome granuloma, spleen, and lamina propria macrophages. " 06/01/2004 - "Granuloma T cells and macrophages expressed preprotachykinin C mRNA. " 06/01/2004 - "Preprotachykinin C mRNA was in murine schistosome granulomas and intestinal lamina propria mononuclear cells. " 08/01/1988 - "It is concluded that substance P is present within the granuloma as a result of preprotachykinin production by eosinophils."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Substance P
3.	Nerve Growth Factor (NGF)
4.	Neurokinin A
5.	Tachykinins
6.	Neurokinin-1 Receptors (Neurokinin 1 Receptor)
7.	Neuropeptides
8.	RNA (Ribonucleic Acid)
9.	Cyclooxygenase 2 (Cyclooxygenase-2)
10.	Carrageenan

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Cesarean Section (Caesarean Section)
3.	Analgesia