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myxovirus resistance proteins

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induced by interferon-alpha/beta; accumulates in nucleus of IFN-treated Mx cells; contributes to resistance against influenza; MW 75,000; human equivalent of mo Mx protein; MxA(R645) has Glu to Arg substitution at carboxy terminus; contains nine sites that are polymorphic in human populations; RefSeq NM_002462 (MX1, human), NM_002463 (MX2, human), NM_013606 (Mx2, mouse), NM_010846 (Mx1, mouse); NM_173096 (Mx1, rat); NM_134350 (Mx2, rat)

Also Known As:

IFI-78K protein, human; IFI78 protein, human; IFI78 protein, rat; MX1 protein, human; MX2 protein, human; Mx protein, mouse; Mx1 protein, mouse; Mx1 protein, rat; Mx2 protein, mouse; Mx2 protein, rat; MxA protein, human; MxA(R645) protein, human; MxB protein, human; interferon inducible protein p78, human; myxovirus (influenza virus) resistance 1 protein, mouse; myxovirus (influenza virus) resistance 2 (mouse) protein, human; myxovirus (influenza virus) resistance 2 protein, mouse; myxovirus (influenza virus) resistance 2 protein, rat; myxovirus (influenza virus) resistance protein, rat; p78-related protein, human; protein Mx; protein Mx, interferon-induced; second interferon-induced protein p78, human

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dahiya, Rajni: 1 article (10/2014)
2.	Sharma, R C: 1 article (10/2014)
3.	Singh, Sandeep: 1 article (10/2014)
4.	Gahlot, S K: 1 article (10/2014)
5.	Manuja, Anju: 1 article (10/2014)
6.	Manuja, Balvinder K: 1 article (10/2014)
7.	Huang, Youhua: 1 article (05/2012)
8.	Wei, Jingguang: 1 article (05/2012)
9.	Guo, Minglan: 1 article (05/2012)
10.	Qin, Qiwei: 1 article (05/2012)

Related Diseases

1.	Infection 10/01/2014 - "The myxovirus resistance protein (Mx) has been reported to confer resistance to Orthomyxo virus infection by modifying cellular functions needed along the viral replication pathway. " 05/01/2012 - "Grouper spleen cells over-expressing EcDefensin (GS/pcDNA-EcDefensin) support the inhibition of viral infection and the upregulation of the expression of host immune-related genes, such as antiviral protein Mx and pro-inflammatory cytokine IL-1β. " 01/01/1992 - "A type-I interferon (IFN)-inducible protein, Mx, was identified in cultured glial cells after infection. " 01/01/1988 - "The establishment of the specific antiviral state against influenza virus correlates with the induction by bovine IFN-alpha, but not -gamma, of two cytoplasmic proteins related to the IFN-induced mouse protein Mx involved in the mechanism of resistance of mice to influenza virus infection. "
2.	Human Influenza (Influenza) 08/01/1987 - "It was also demonstrated that p78 and the protein Mx of influenza-resistant mice, which we purified and characterized earlier (Horisberger and Hochkeppel, J. " 01/15/1985 - "In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells) interferon-alpha/beta (IFN) induces an efficient antiviral state against influenza viruses and, concomitantly, the synthesis of a 75,000-Da protein (protein Mx). " 05/01/2008 - "The immune molecules analyzed include (i) inflammatory molecules, such as interleukin-1b (il1b), il6, tumor necrosis factor-a (tnfa), cyclooxygenase-2 (cox2) and the NADPH oxidase subunit p40(phox) (ncf4 gene); (ii) the anti-inflammatory cytokine transforming growth factor-b1 (tgfb1) and its type 2 receptor tgfbr2; (iii) innate immune receptors, including toll-like receptor 9 (tlr9), tlr5, tlr22 and macrophage-colony stimulating factor receptor (mcsfr); (iv) lymphocyte receptors, such as the beta subunit of T-cell receptor (Tcrb) and the heavy chain of immunoglobulin M (ighm); (v) the anti-bacterial molecules lysozyme (lyz), hepcidin (hamp) and complement component 3 (c3); (vi) the anti-viral molecule myxovirus (influenza) resistance protein (mx); and (vii) molecules related to leukocyte infiltration, including the CC chemokine ccl4, the CXC chemokine il8 and the leukocyte adhesion molecule E-selectin (Sele). "
3.	Necrosis 02/01/2011 - "We characterized the secretion of tumour necrosis factor (TNF)-α in primary macrophage cultures of rainbow trout (Oncorhynchus mykiss) in response to several PAMPs by Western blot and compared this to the induction of TNF-α gene expression as well as other pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and anti-viral molecules such as INF-α and Mx protein (Mx). "
4.	Myxoma (Myxomas) 12/01/2009 - "We examined the mRNA expression levels of TIPE2 and myxoma resistance protein (MX) 1 (one of type I interferon inducible genes) in peripheral blood mononuclear cells (PBMC) from 39 SLE patients and 35 healthy controls by real-time reverse transcription-polymerase chain reaction analysis (RT-PCR). "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Interferon Type I
3.	Chemokine CCL4
4.	Cyclooxygenase 2 (Cyclooxygenase-2)
5.	Toll-Like Receptor 9
6.	NADPH Oxidase (NAD(P)H oxidase)
7.	E-Selectin
8.	Interferon-alpha (Interferon Alfa)
9.	Interleukin-8 (Interleukin 8)
10.	Cytokines