Pseudomonas aeruginosa pseudolysin

Also Known As:

pseudolysin, Pseudomonas aeruginosa; LasB protein, Pseudomonas aeruginosa; Legionella zinc metalloprotease; Pseudomonas aeruginosa elastase; zinc metalloproteinase, Legionella pneumophila

Networked: 21 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Bacterial Proteins: 394
    - Pseudomonas aeruginosa pseudolysin: 21
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        Pseudomonas aeruginosa pseudolysin: 21
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        Pseudomonas aeruginosa pseudolysin: 21

Experts

1.	Alhayek, Alaa: 1 article (01/2020)
2.	Andreas, Anastasia: 1 article (01/2020)
3.	Berger, Fabian K: 1 article (01/2020)
4.	Bischoff, Markus: 1 article (01/2020)
5.	Brandstetter, Hans: 1 article (01/2020)
6.	Hartmann, Rolf W: 1 article (01/2020)
7.	Haupenthal, Jörg: 1 article (01/2020)
8.	Hirsch, Anna K H: 1 article (01/2020)
9.	Kany, Andreas M: 1 article (01/2020)
10.	Koehnke, Jesko: 1 article (01/2020)

Related Diseases

1.	Infections 01/01/2020 - "It has been shown that Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum (Hathewaya histolytica) collagenase (ColH) play a significant role in the infection process and thereby represent promising antivirulence targets. " 05/01/2000 - "Immunization with a Pseudomonas aeruginosa elastase peptide reduces severity of experimental lung infections due to P. " 09/01/1984 - "Experimental studies of the pathogenesis of infections owing to Pseudomonas aeruginosa: elastase, an IgG protease." 11/01/1982 - "Pseudomonas aeruginosa elastase is a zinc metalloendopeptidase, probably responsible for the tissue destruction observed during infections with this organism. " 06/01/2002 - "The aim of this study was to identify antibiotics used for the treatment of infection in cystic fibrosis that may alter the activity of human neutrophil elastase (HNE) and Pseudomonas aeruginosa elastase (PE). "
2.	Keratitis 01/01/1987 - "Specific inhibitors of Pseudomonas aeruginosa elastase as potential drugs for the treatment of Pseudomonas keratitis." 12/01/1994 - "Suppression of polymorphonuclear leucocyte chemotaxis by Pseudomonas aeruginosa elastase in vitro: a study of the mechanisms and the correlation with ring abscess in pseudomonal keratitis." 09/01/1993 - "The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis." 04/01/1984 - "The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes." 11/01/1990 - "Inhibition of Pseudomonas aeruginosa elastase and Pseudomonas keratitis using a thiol-based peptide."
3.	Cystic Fibrosis (Mucoviscidosis) 12/01/1989 - "Functional importance of cystic fibrosis immunoglobulin G fragments generated by Pseudomonas aeruginosa elastase." 04/01/1995 - "Secretion of Pseudomonas aeruginosa elastase, exotoxin A, and alkaline protease in sputum during bronchopulmonary exacerbations was examined in 18 cystic fibrosis patients chronically infected with this microorganism. " 06/01/2002 - "The aim of this study was to identify antibiotics used for the treatment of infection in cystic fibrosis that may alter the activity of human neutrophil elastase (HNE) and Pseudomonas aeruginosa elastase (PE). " 06/01/2002 - "Colistin increases the activity of human neutrophil elastase and Pseudomonas aeruginosa elastase, two proteases that contribute to the pathogenesis of cystic fibrosis airway disease."
4.	Abscess 12/01/1994 - "Suppression of polymorphonuclear leucocyte chemotaxis by Pseudomonas aeruginosa elastase in vitro: a study of the mechanisms and the correlation with ring abscess in pseudomonal keratitis." 09/01/1993 - "The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis."
5.	Shock 08/01/1994 - "An intravenous injection of 1.2 mg/kg of Pseudomonas aeruginosa elastase induces immediate lethal shock in guinea-pigs. " 08/04/1993 - "Intravenous or intracardiac injection of purified Pseudomonas aeruginosa elastase (1.2 mg/kg) but not endotoxin (up to 2.0 mg/kg) reproduced the immediate shock followed by death within 45 min in anesthetized or in conscious guinea pigs. "

Related Drugs and Biologics

1.	Leukocyte Elastase (Neutrophil Elastase)
2.	Peptide Hydrolases (Proteases)
3.	Immunoglobulin G (IgG)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Peptides (Polypeptides)
6.	Cathepsin G
7.	Complex Mixtures
8.	Collagenases (Collagenase)
9.	Zinc
10.	Surface-Active Agents (Surfactants)

Related Therapies and Procedures

1.	Intravenous Injections