RA VII

07/01/2006 - "A careful dose setting of RA-VII is crucial to obtain therapeutic superiority, possibly through tumor vessel maturation and a better distribution of the compound in the tumor tissue."
07/01/2006 - "These results indicate that metronomic scheduling of RA-VII is efficient for cancer treatment. "
07/01/2006 - "Interestingly, although two doses of RA-VII decreased the tumor vascular area to a similar extent, a higher dose of RA-VII led to tumor vessel maturation together with a significant increase in tumor cell apoptosis. "
07/01/2006 - "We then applied RA-VII for the treatment of tumors in mice. "
07/01/2006 - "Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity."

11/01/1987 - "In P388 leukemia (inoculated intraperitoneally (i.p.), administered i.p.: i.p.-i.p.) the maximal increase in life span (ILSmax) resulting from an administration of RA-700 (4 mg/kg/d for 9 d) was 134% and the therapeutic ratio was 400. "
11/01/1987 - "In the study of a model of the inhibition of lymph node metastasis using P388 leukemia, the administration of RA-700 at more than 2.5 mg/kg/d i.v. for 7 d resulted in the survival of all animals (5/5) for over 60 d. "
07/01/1993 - "Several aromatic ring substituent modified RA derivatives were prepared from RA-VII (1), RA-V (8) and RA-II (11), and evaluated for cytotoxicity against P388 leukemia and KB cells. "
05/01/1987 - "The antitumor activity of RA-700 was similar to that of deoxy-bouvardin and VCR against P388 leukemia. "
08/01/1993 - "A number of RA-VII derivatives having various amino acids including proline (6), pipecolic acid (11), norvaline (12), ornithine (14), aspartic acid (15) and methionine (20) in place of Ala2 have been synthesized from RA-X methyl ester (3) and evaluated for cytotoxicity to P388 leukemia and KB cells in vitro. "

02/01/1994 - "Then we tried to study several kinds of parameters, for instance ECG, ultrasonic cardiograms and arterio-grams on cardiac toxicities of RA-700. "

11/01/1987 - "In the study of a model of the inhibition of lymph node metastasis using P388 leukemia, the administration of RA-700 at more than 2.5 mg/kg/d i.v. for 7 d resulted in the survival of all animals (5/5) for over 60 d. "

01/01/1986 - "From the results of the study using the human tumor cell line of lung cancer (PC-6), RA-700 appears to possess time-dependent antitumor activity. "