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polylactic acid-polyglycolic acid copolymer (PLGA)

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copolymer of 75% polylactic acid & 25% polyglycolic acid; also as copolymer of 70% polylactic acid and 30% polyglycolic acid

Also Known As:

PLGA; LactoSorb; PL-PG copolymer; PLG polymer; poly(D,L-lactide-co-glycolide); poly(L-lactide)-co-glycolide (70-30); poly(glycolide-co-lactide); poly(lactic-co-glycolic acid); polylactic-co-glycolic acid copolymer

Networked: 1330 relevant articles (138 outcomes, 269 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Chi-Hwa: 13 articles (11/2013 - 05/2003)
2.	Mei, Lin: 12 articles (07/2015 - 01/2010)
3.	Zheng, Yuanyi: 10 articles (01/2016 - 06/2012)
4.	Wang, Zhigang: 9 articles (01/2016 - 06/2012)
5.	Duan, Yourong: 9 articles (12/2015 - 01/2012)
6.	Atyabi, Fatemeh: 9 articles (08/2015 - 01/2011)
7.	Zeng, Xiaowei: 9 articles (07/2015 - 01/2013)
8.	Feng, Si-Shen: 9 articles (11/2014 - 04/2007)
9.	Khuda-Bukhsh, Anisur Rahman: 9 articles (03/2014 - 09/2010)
10.	Lee, Hai Bang: 9 articles (06/2012 - 09/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2011 - "These results suggest that the novel FOL-PEG-PLGA NPs could be a potential delivery system with excellent therapeutic efficacy for targeting the drugs to cancer cells." 02/01/2011 - "CPT-PLGA nanoparticles stereotactically delivered by CED improved survival in rats with intracranial 9L tumors: the median survival for rats treated with CPT-PLGA nanoparticles (22 days) was significantly longer than unloaded nanoparticles (15 days) and free CPT infusion (17 days). " 07/01/2008 - "In addition, the PLGA/PbAE blend nanoparticles were effective in enhancing the residence time of both drugs at the tumor site by reducing systemic clearance. " 10/01/2014 - "Furthermore, the anticancer efficacy of TFLPs on the tumor spheroids was stronger than that of lipid coated PLGA nanoparticles (LPs) and PLGA nanoparticles. " 01/01/2014 - "Together, these findings suggest that PLGA-based nanoformulation could potentially serve as a safe and effective nanovector platform for miR-150 delivery to pancreatic tumor cells. "
2.	Infection 12/01/2015 - "Lymphocyte proliferation assay as a marker of amplification in cellular immunity demonstrated that the splenocytes of the immunized mice had a high proliferation index with reference to the control, revealing that L7/L12 entrapping PLGA nanoparticles are potent inducer of inflammatory cell response indispensable to combat Brucella infection. " 10/01/2013 - "Presently, we explored the ability of the recombinant PLGA nanoparticles to stimulate innate responses in macrophages and the outcome of infection with Leishmania braziliensis in vitro. " 02/01/2005 - "Verified infection of contaminated SS screws was collaborated by the increased 18F-FDG-PET uptake (P=0.004 compared with the group of contaminated Ab-PLGA screws). " 09/01/1998 - "For those patients reviewed, the following information is included: age, sex, diagnosis, surgical procedures, number and size of LactoSorb plates and screws used in each patient, operative difficulty of the screws and the heat pack, and postoperative complications, including wound healing, palpability, and infection. " 07/01/2014 - "The in vitro cytotoxic response of the T-lymphocytes revealed that AmB-PLGA-nanospheres efficacy against VL infection was strictly due to the action of CD8(+)- but not CD4(+)-T lymphocytes. "
3.	Glioma (Gliomas) 11/01/2013 - "Overall, MNP-MSN-PLGA-Tf NPs are promising carriers for the delivery of dual drugs for effective treatment of brain glioma." 08/01/2006 - "The present study aims to develop electrospun PLGA-based micro- and nanofibers as implants for the sustained delivery of anticancer drug to treat C6 glioma in vitro. " 07/01/2014 - "Pep-1 was functionalized to the surface of PEG-PLGA nanoparticles (Pep-NP) to evaluate its glioma homing, by taking advantage of the excessive expression of the IL-13Rα2 on the surface of glioma cells. " 01/01/2014 - "In the current research work, an attempt has been made to understand the anti-metastatic effect of the drug after loading into PLGA nanoparticles against C6 glioma cells.Nanoparticles" 05/10/2012 - "Therapeutic effect (mean survival) was evaluated in the C6 rat glioma model (control group, 18 days; CPT/PLGA/TGP treatment group, 24 days; VCR/PLGA/TGP treatment group, 33 days). "
4.	Glioblastoma (Glioblastoma Multiforme) 12/07/2015 - "We hypothesized that PLGA nanoparticles carrying antisense miR-21 to glioblastoma cells might beneficially knock down endogenous miR-21 prior to TMZ treatment. " 03/01/2015 - "Regarding biodistribution, the strongest brain-localized fluorescence signals were detected in glioblastoma multiforme (GBM)-bearing rats treated with 1,10-Dioctadecyl-3,3,30,30-tetramethylindotricarb-ocyanine iodide (DiR)-loaded RGD-L-P, compared to rats treated with DiR-loaded L-P or PLGA-P. " 01/01/2014 - "Impregnation with Pt enhanced the uptake of PLGA NPs in U87 glioblastoma cells as compared to PLGA NPs by following endocytosis mechanism. " 07/01/2002 - "These results suggest that PLGA/PEG microparticles are useful as delivery vehicles for controlled release of ODNs and merit further investigation in cell culture and animal models of glioblastoma." 10/21/2012 - "The magnetic PLGA/MPLs nanosphere may be another option for treatment of glioblastoma."
5.	Tuberculosis (Tuberculoses) 03/01/2010 - "Based on these results, RFP-PLGA MS will be effective for the delivery of anti-tuberculosis drugs such as RFP, and will be a potentially useful drug delivery tool for pulmonary and possibly other tissues as well." 10/15/2011 - "In contrast, the phagocytosis of PSL MS did not enhance the phagocytic activity of Mϕ cells toward F-PSL MS. In conclusion, R-PLGA MS are favorable for drug delivery of anti-tuberculosis agents into alveolar Mϕs due to their ability to up-regulate the phagocytosis of MS." 02/28/2013 - "It was concluded by these studies combined with our previous reports that spray-dried PLGA nanoparticles demonstrate potential for the improvement of tuberculosis chemotherapy by nanoencapsulation of anti-tuberculosis drugs." 03/19/2010 - "We conclude that RFP-PLGA MS are bio-safe microspheres due to their "silent" nature when taken into M phi cells and that they are promising for the treatment of tuberculosis by pulmonary inhalation." 06/01/2008 - "Mycobacterial infection stimulated the phagocytic uptake toward cPLGA MS. These results suggest that RFP-PLGA MS is favorable for overcoming tuberculosis."

Related Drugs and Biologics

1.	polylactic acid-polyglycolic acid copolymer (PLGA)
2.	Carbon Monoxide
3.	glycolic acid (glycolate)
4.	DNA (Deoxyribonucleic Acid)
5.	Polymers
6.	Antigens
7.	Small Interfering RNA (siRNA)
8.	Hydrogel
9.	Polyglactin 910
10.	poly(lactide) (polylactide)

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Lasers (Laser)
5.	Immunotherapy