vanoxerine (I 893)

structure given in first source

Also Known As:

I 893; 1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine; 1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride; GBR 12909; GBR-12909; I-893; vanoxeamine

Networked: 49 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - vanoxerine: 49

Experts

1.	Brown, Arthur M: 5 articles (11/2015 - 03/2010)
2.	Waldo, Albert L: 4 articles (06/2015 - 03/2010)
3.	Dittrich, Howard C: 3 articles (01/2016 - 06/2015)
4.	Lacerda, Antonio E: 3 articles (11/2011 - 03/2010)
5.	Venanzi, Carol A: 3 articles (01/2011 - 05/2005)
6.	Rothman, Richard B: 3 articles (01/2008 - 03/2002)
7.	Kamińska, Kinga: 2 articles (06/2021 - 11/2019)
8.	Lorenc-Koci, Elżbieta: 2 articles (06/2021 - 11/2019)
9.	Rogóż, Zofia: 2 articles (06/2021 - 11/2019)
10.	Camm, A John: 2 articles (01/2016 - 06/2015)

Related Diseases

1.	Atrial Fibrillation 01/01/2016 - "RESTORE SR (randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial fibrillation or flutter to normal sinus rhythm) was a prospective, multinational, randomized, double-blind, placebo-controlled trial that randomized subjects to a single oral dose of vanoxerine 400 mg or placebo (2:1 allocation). " 01/01/2016 - "Randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent onset atrial fibrillation or flutter to normal sinus rhythm: RESTORE SR." 06/01/2015 - "COR-ART: A multicenter, randomized, double-blind, placebo-controlled dose-ranging study to evaluate single oral doses of vanoxerine for conversion of recent-onset atrial fibrillation or flutter to normal sinus rhythm." 01/01/2021 - "Based on these profiles on ionic currents, vanoxerine has been developed as a candidate compound for treating atrial fibrillation. " 11/30/2015 - "Vanoxerine's effects were strongly frequency-dependent and we repositioned it for treatment of atrial fibrillation and flutter. "
2.	Cocaine-Related Disorders (Cocaine Addiction) 10/01/2000 - "In 1989, it was suggested that GBR-12909 might be useful in the treatment of cocaine addiction [346980]. " 11/30/2015 - "Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. " 01/01/2011 - "Analogs of the flexible dopamine reuptake inhibitor, GBR 12909 (1), may have potential utility in the treatment of cocaine abuse. " 05/01/2005 - "This paper describes a novel clustering methodology for classifying over 700 conformations of a flexible analogue of GBR 12909, a dopamine reuptake inhibitor that has completed phase I clinical trials as a treatment for cocaine abuse. " 09/01/2001 - "Vanoxerine (1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine; GBR12909) is a promising agent for the treatment of cocaine dependence. "
3.	Atrial Flutter (Flutter, Atrial) 01/01/2016 - "The purpose of this study was to evaluate the safety and efficacy of vanoxerine for the restoration of sinus rhythm in subjects with recent onset AF or atrial flutter (AFL). " 11/01/2011 - "The purpose of this study was to test the hypothesis that oral dosing of vanoxerine would first terminate induced atrial flutter (AFL) and atrial fibrillation (AF), and then prevent their reinduction. " 03/01/2010 - "In these studies, we tested the hypothesis that vanoxerine would terminate induced atrial fibrillation (AF) and atrial flutter (AFL) in dogs with sterile pericarditis (SP). "
4.	Neoplasms (Cancer) 12/01/2021 - "Finally, in vivo study in BALB/C nude mice subcutaneously xenografted with Huh7 cells, vanoxerine dihydrochloride (40 mg/kg, i.p.) injection for 21 days produced significant anti-tumor activity (p < 0.05), which was comparable to that achieved by 5-Fu (10 mg/kg, i.p.), with the combination treatment resulted in synergistic effect. " 12/18/2020 - "It was revealed that 3 compounds (vanoxerine, tolnaftate, and gabexate) may help to prolong the disease-free survival time from tumor metastasis of patients with the tumor. "
5.	Neoplasm Metastasis (Metastasis) 12/18/2020 - "It was revealed that 3 compounds (vanoxerine, tolnaftate, and gabexate) may help to prolong the disease-free survival time from tumor metastasis of patients with the tumor. "

Related Drugs and Biologics

1.	Gabexate (Foy)
2.	Tolnaftate (Ting)
3.	Piperazine
4.	Cocaine (Cocaine HCl)
5.	Glutathione (Reduced Glutathione)
6.	Dopamine (Intropin)
7.	1-(2 (diphenylmethoxy)ethyl)- 4- (3- phenylpropyl)piperazine
8.	Dopamine Uptake Inhibitors (Dopamine Reuptake Inhibitors)
9.	Desipramine (Pertofrane)
10.	buthionine

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Analgesia
3.	Therapeutics
4.	Electric Countershock (Cardioversion)
5.	Drug Therapy (Chemotherapy)