6,6'-dicorynomycolyl trehalose

Also Known As:

6,6'-dicorynomycolyl alpha, alpha'-trehalose; 6,6'-dicorynomycolyl beta, beta'-trehalose; DCYMT; S-TDCM; trehalose 6,6'-dicorynomycolate; trehalose dicorynomycolate; beta-D-Glucopyranoside, 6-O-(3-hydroxy-1-oxo-2-tetradecyloctadecyl)-beta-D-glucopyranosyl, (3aS-(3aalpha,4beta,6aalpha))-

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bolduc, David L: 1 article (01/2015)
2.	Elliott, Thomas B: 1 article (01/2015)
3.	Fatanmi, Oluseyi O: 1 article (01/2015)
4.	Kiang, Juliann G: 1 article (01/2015)
5.	Ledney, G David: 1 article (01/2015)
6.	Newman, Victoria L: 1 article (01/2015)
7.	Romaine, Patricia L P: 1 article (01/2015)
8.	Singh, Vijay K: 1 article (01/2015)
9.	Wise, Stephen Y: 1 article (01/2015)
10.	Ali, Nahid: 1 article (01/2012)

Related Diseases

1.	Visceral Leishmaniasis (Kala Azar) 01/01/2012 - "Vaccination with liposomal leishmanial antigens adjuvanted with monophosphoryl lipid-trehalose dicorynomycolate (MPL-TDM) confers long-term protection against visceral leishmaniasis through a human administrable route."
2.	Wounds and Injuries (Trauma) 01/01/1992 - "Synthetic trehalose dicorynomycolate and antimicrobials increase survival from sepsis in mice immunocompromised by radiation and trauma." 03/01/1991 - "These studies demonstrate that post-trauma therapy with S-TDCM and antibiotics augments resistance to infection in immunocompromised mice. " 01/01/1992 - "We determined that postirradiation therapy with the immunomodulator synthetic trehalose dicorynomycolate (S-TDCM) and antimicrobials increases survival in mice after lethal irradiation and tissue trauma. " 03/01/1991 - "Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM)."
3.	Infections 10/01/1991 - "Therapy with S-TDCM for mice irradiated with either a mixed field or gamma rays increased resistance to Klebsiella pneumoniae-induced infections. " 10/01/1991 - "In lethal models of acquired infections in irradiated-wounded mice, significant increases in survival were achieved when systemic treatments with S-TDCM or gentamicin were combined with topical treatments of gentamicin cream. " 10/01/1991 - "In all irradiated-wounded mice, single therapy of acquired infections with an antibiotic or S-TDCM did not increase survival. " 03/01/1991 - "We recently showed that injection of synthetic trehalose dicorynomycolate (S-TDCM) significantly augments resistance to infection and increases survival of mice compromised either by whole-body irradiation with gamma radiation or equal mixtures of fission neutron and gamma radiation. " 03/01/1991 - "These studies demonstrate that post-trauma therapy with S-TDCM and antibiotics augments resistance to infection in immunocompromised mice. "
4.	Sepsis (Septicemia) 01/01/1992 - "Synthetic trehalose dicorynomycolate and antimicrobials increase survival from sepsis in mice immunocompromised by radiation and trauma." 10/01/1994 - "Ofloxacin or combined ofloxacin and S-TDCM increased survival from the gram-negative bacterial sepsis that predominated in n/gamma=1 irradiated mice. " 03/01/1991 - "Treatment of mice with sepsis following irradiation and trauma with antibiotics and synthetic trehalose dicorynomycolate (S-TDCM)." 01/01/2015 - "A combination therapy for combined injury (CI) using a non-specific immunomodulator, synthetic trehalose dicorynomycolate and monophosphoryl lipid A (STDCM-MPL), was evaluated to augment oral antimicrobial agents, levofloxacin (LVX) and amoxicillin (AMX), to eliminate endogenous sepsis and modulate cytokine production. "
5.	Body Weight (Weight, Body) 03/01/1997 - "Toxicity of S-TDCM was measured in nonirradiated mice by locomotor activity, food intake, water consumption, and alterations in body weight. "

Related Drugs and Biologics

1.	Lipids
2.	Antigens
3.	Anti-Bacterial Agents (Antibiotics)
4.	6,6'-dicorynomycolyl trehalose
5.	Immunologic Factors (Immunomodulators)
6.	Levofloxacin (Levaquin)
7.	Cytokines
8.	Ofloxacin (Ofloxacine)
9.	Gentamicins (Gentamicin)
10.	Anti-Infective Agents (Microbicides)

Related Therapies and Procedures

1.	Therapeutics