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KME 4

structure given in first source

Also Known As:

KME-4; alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)gamma-butyrolactone

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - 4-Butyrolactone: 81
    - KME 4: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - 4-Butyrolactone: 81
      - KME 4: 4

Related Diseases

1.	Pleurisy (Pleuritis) 03/01/1986 - "When administered orally 1 h before carrageenan, KME-4 (3-10 mg kg-1) induced a degree of inhibition of leucocyte migration almost equal to that of indomethacin (3-10 mg kg-1) in both 5 h and 24 h pleurisies. " 03/01/1986 - "Furthermore, KME-4, when administered orally 5 h after the carrageenan, inhibited both monocyte numbers and exudate volume in a 24 h pleurisy and was more effective than indomethacin and BW755c which inhibited only monocyte migration. "
2.	Leukemia 09/01/1984 - "Furthermore, KME-4 was found to be equipotent in inhibiting both prostaglandin synthetase and 5-lipoxygenase activities of rat basophilic leukemia cells, unlike indomethacin, naproxen and ibuprofen. "
3.	Granuloma 09/01/1984 - "The ratio of UD50 stomach to ED30 carrageenin edema or to ED25 granuloma for KME-4 showed higher values than those of the reference drugs. "
4.	Fever (Fevers) 09/01/1984 - "KME-4 showed antipyretic activity in yeast-induced fever in rats. "
5.	Edema (Dropsy) 09/01/1984 - "The ratio of UD50 stomach to ED30 carrageenin edema or to ED25 granuloma for KME-4 showed higher values than those of the reference drugs. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Carrageenan
3.	Antipyretics
4.	4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
5.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.	Naproxen (Naprosyn)
7.	Ibuprofen (Motrin)
8.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)