HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

carvedilol (Coreg)

structure given in first source; has alpha as well as beta blocking activity

Also Known As:

Coreg; Atlana Pharma brand of carvedilol; BM 14190; BM-14190; Coropres; Dilatrend; Eucardic; GlaxoSmithKline brand of carvedilol; Kredex; Lakeside brand of carvedilol; Querto; Roche brand of carvedilol; carvedilol, (+-)-isomer; carvedilol, (R)-isomer; carvedilol, (S)-isomer; carvedilol, 14C-labeled

Networked: 1497 relevant articles (267 outcomes, 522 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lukas, Mary Ann: 24 articles (01/2011 - 02/2003)
2.	Torp-Pedersen, Christian: 20 articles (06/2014 - 06/2002)
3.	Cleland, John G F: 19 articles (02/2010 - 06/2002)
4.	Metra, Marco: 18 articles (02/2010 - 02/2002)
5.	Swedberg, Karl: 16 articles (01/2015 - 06/2002)
6.	Komajda, Michel: 15 articles (01/2015 - 06/2002)
7.	Di Lenarda, Andrea: 14 articles (11/2007 - 06/2002)
8.	Remme, Willem J: 13 articles (11/2007 - 07/2003)
9.	Gilbert, Edward M: 11 articles (04/2015 - 05/2002)
10.	Bakris, George L: 11 articles (09/2010 - 11/2004)

Related Diseases

1.	Heart Failure 06/01/2002 - "This suggests that carvedilol therapy for patients with severe chronic heart failure is not only safe and effective but is highly cost effective in the Irish healthcare setting." 04/01/1996 - "The Australia and New Zealand carvedilol heart failure study is the largest completed study of beta-blocker treatment in patients with heart failure of ischaemic aetiology, including 415 patients randomized to carvedilol or placebo and indicating excellent tolerability of a titrated dose regimen and improved ventricular function after 6 months of treatment. " 03/01/2011 - "We hypothesized that carvedilol might be another safe treatment option in chronic AR, considering its combined β-blocking and α-blocking effects and proven efficacy in patients with established heart failure. " 10/16/2007 - "One drug, carvedilol, a nonsubtype-selective betaAR antagonist, has proven particularly effective in the treatment of heart failure, although the mechanism(s) responsible for this are controversial. " 09/01/2007 - "Safety and efficacy of carvedilol in very elderly diabetic patients with heart failure."
2.	Hypertension (High Blood Pressure) 01/01/1994 - "This study showed that carvedilol is safe and effective in the treatment of mild to moderate hypertension and that there is a high prevalence (nearly 40%) of low ambulatory blood pressure means in a population labelled as mild to moderate hypertensive." 01/01/2011 - "It was concluded that there were no clinically significant issues in terms of safety or efficacy with the long-term treatment of carvedilol in patients with hypertension." 01/01/2012 - "Multiple-unit system exhibited enhanced bioavailability and sustained release of carvedilol, indicating its improved therapeutic potential for the treatment of hypertension." 03/01/2000 - "We thus selected carvedilol, a beta-blocker with slight alpha-blocking action, and were more effective in abolishing the hypertension." 01/01/1987 - "The present study also suggests that low-dose carvedilol once daily may be effective in the treatment of hypertension."
3.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/01/2009 - "The results of the present study indicate that carvedilol is well tolerated in children with dilated cardiomyopathy and there is a significant improvement in the clinical status and left ventricular ejection fraction in patients not responding to conventional therapy. " 01/01/2001 - "Carvedilol is well tolerated in infants with dilated cardiomyopathy and there is significant improvement in their functional status. " 08/01/2000 - "Notably, by the end of the first month of treatment, the antiarrhythmic efficacy of the drug was significantly greater in patients with ischaemic than in those with idiopathic dilated cardiomyopathy, an effect that could probably be attributed to the anti-ischaemic properties of carvedilol. " 08/01/2000 - "Efficacy of carvedilol on complex ventricular arrhythmias in dilated cardiomyopathy: double-blind, randomized, placebo-controlled study." 03/01/2007 - "In conclusion, carvedilol therapy is associated with improvement in both LV and LA functions in nonischemic dilated cardiomyopathy. "
4.	Cardiomyopathies (Cardiomyopathy) 12/01/2005 - "As it follows from our experience dilatrend is very effective for treatment of dilatative cardiomyopathy of alcoholic genesis." 11/01/2004 - "Five cases of anthracycline-induced cardiomyopathy effectively treated with carvedilol." 01/01/1996 - "In ischemic cardiomyopathy, carvedilol appears to be effective to improve prognosis. " 03/01/2011 - "Carvedilol exerted protective effects against volume-overload cardiomyopathy in this model of aortic valve regurgitation with preserved ejection fraction. " 12/05/2006 - "Protective effects of carvedilol against anthracycline-induced cardiomyopathy."
5.	Myocardial Infarction 04/01/1996 - "In addition to the safety and efficacy of carvedilol as an antihypertensive agent, experimental studies indicate that carvedilol also provides significant cardioprotection in animal models of acute myocardial infarction as well as protection against the vascular remodelling that occurs following injury of the vasculature. " 12/01/2007 - "Given that carvedilol exhibits ancillary pharmacologic proprieties beneficial in CIACS, and post-myocardial infarction mortality data are available regarding its use, this agent could be considered to be appropriate therapy." 07/01/2007 - "Carvedilol has previously been demonstrated to be beneficial in patients with acute myocardial infarction (AMI) and left ventricular (LV) dysfunction. " 09/01/2010 - "Carvedilol ameliorates sympathetic nerve sprouting and electrical remodeling after myocardial infarction in rats." 05/05/2001 - "In patients treated long-term after an acute myocardial infarction complicated by left-ventricular systolic dysfunction, carvedilol reduced the frequency of all-cause and cardiovascular mortality, and recurrent, non-fatal myocardial infarctions. "

Related Drugs and Biologics

1.	Metoprolol (Lopressor)
2.	Propranolol (Inderal)
3.	Bisoprolol (Concor)
4.	nebivolol
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6.	Atenolol (Tenormin)
7.	Diuretics
8.	Amiodarone (Amiodarona)
9.	metoprolol succinate (Toprol-XL)
10.	Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Electric Countershock (Cardioversion)