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pelanserin
RN given refers to parent cpd
Also Known As:
2,4(1H,3H)-quinazolinedione-3-(3-(4-phenyl-1-piperazinyl)propyl) hydrochloride; TR 2515; TR-2515; TR2515; pelanserin monohydrochloride
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
pelanserin: 3
Related Diseases
1.
Hypertension (High Blood Pressure)
07/01/1990 - "
The pharmacokinetic and pharmacodynamic profiles of pelanserin allow to predict that this drug could have a place in the therapeutics of arterial hypertension.
"
05/01/1994 - "
It has been postulated that hypofunction of 5-HT1A receptors, or the exaggerated stimulation of 5-HT2 receptor may be associated with arterial hypertension and that agonists of the first type (indorenate or 8-OH-DPAT) or antagonists of the second type (ketanserin or pelanserin) allow the control of arterial hypertension.
"
09/01/1992 - "
It is concluded that pelanserin pharmacokinetic and pharmacodynamic profiles in dogs are adequate for an antihypertensive agent, therefore this drug possesses potential therapeutic usefulness in the treatment of hypertension.
"
2.
Thromboembolism
05/01/1994 - "
On the other land, ketanserin and pelanserin attenuated the hemodynamic manifestations in an experimental model of thromboembolism, suggesting that 5-HT is involved in such phenomenon.
"
3.
Tachycardia (Tachyarrhythmias)
07/01/1990 - "
On the other hand, oral administration of pelanserin resulted in a significant antihypertensive effect that was not followed by tachycardia.
"
Related Drugs and Biologics
1.
Antihypertensive Agents (Antihypertensives)
2.
Serotonin (5 Hydroxytryptamine)
3.
Ketanserin
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration