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fosphenytoin (Cerebyx)

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structure given in first & second source

Also Known As:

Cerebyx; 3-(hydroxymethyl)phenytoin disodium phosphate; 3-(hydroxymethyl)phenytoin phosphate ester; ACC 9653; ACC-9653; HMPDP; Prodilantin; fosphenytoin sodium; fosphenytoin, disodium salt; 2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, (SP-4-2)-

Networked: 106 relevant articles (8 outcomes, 12 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Imidazoles: 107
      - Imidazolidines: 6
        Hydantoins: 47
        Phenytoin: 4616
        fosphenytoin: 106

Experts

1.	Ogutu, Bernhards R: 3 articles (12/2013 - 12/2002)
2.	Muchohi, Simon N: 3 articles (12/2013 - 12/2002)
3.	Kälviäinen, Reetta: 3 articles (06/2009 - 01/2005)
4.	Eriksson, Kai: 3 articles (06/2009 - 01/2005)
5.	Nakazawa, Mika: 2 articles (10/2015 - 04/2015)
6.	Shimizu, Toshiaki: 2 articles (10/2015 - 04/2015)
7.	Niijima, Shinichi: 2 articles (10/2015 - 04/2015)
8.	Okumura, Akihisa: 2 articles (10/2015 - 04/2015)
9.	Coles, Lisa D: 2 articles (06/2015 - 06/2015)
10.	Patterson, Edward E: 2 articles (06/2015 - 06/2015)

Related Diseases

1.	Status Epilepticus (Complex Partial Status Epilepticus) 01/01/2015 - "The safety and efficacy of fosphenytoin for the treatment of status epilepticus." 06/01/2015 - "Canine status epilepticus treated with fosphenytoin: A proof of principle study." 02/01/2004 - "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus. " 06/01/2015 - "Use of IV fosphenytoin pharmacokinetics to determine the loading dose for a clinical trial of canine status epilepticus." 04/23/2014 - "If status epilepticus continued at 12 minutes, fosphenytoin was administered. "
2.	Seizures (Seizure) 10/01/2015 - "The efficacy of fosphenytoin was categorized as effective when cessation of seizures was achieved. " 10/01/1998 - "Additional studies may provide more pharmacoeconomic data to support the greater use of fosphenytoin in the treatment of acute pediatric seizures." 10/01/2015 - "Patients were randomised to receive LEV, 500 mg/body every 12 h until postoperative day 7, or PHT, 15-18 mg/kg fosphenytoin followed by 125 mg PHT every 12 h until postoperative day 7. The primary end point was the occurrence of seizures, and secondary end points included the occurrence of haematological and non-haematological adverse events. " 10/01/2015 - "Seizures were completely controlled after the initial dose of fosphenytoin in 14 of 16 patients. " 04/01/2015 - "To evaluate the efficacy and safety of fosphenytoin (fPHT) for the treatment of seizures in children with acute encephalopathy. "
3.	Bipolar Disorder (Mania) 04/01/2003 - "Seven patients with a DSM-IV manic episode and minimal prior drug treatment were given intravenous fosphenytoin and were assessed at baseline and after 15, 30, 45, and 60 minutes with the Young Mania Rating Scale, the Clinical Global Impressions scale, and the Mini-Mental State Examination. " 04/01/2003 - "Intravenous fosphenytoin in acute mania." 04/01/2003 - "Intravenous fosphenytoin at doses that are effective in status epilepticus appears to be ineffective in acute mania."
4.	Hypotension (Low Blood Pressure) 12/01/2002 - "One patient developed hypotension (fosphenytoin); there were no other serious adverse events, including phlebitis. " 02/01/1997 - "Systemic toxicity is similar with both preparations except that hypotension is less common and paresthesias are more common with fosphenytoin." 12/01/2009 - "To study the incidence and extent of the occasionally noted hypotension after intravenous (IV) infusions of fosphenytoin (FOS) and levetiracetam (LEV) in patients presenting with acute cerebral symptoms. " 01/01/2005 - "Cardiac complications such as arrhythmias and hypotension are rare in cases of phenytoin ingestion, but they may be seen in parenteral administration of phenytoin or fosphenytoin. " 04/01/2010 - "The patient presented with an intracranial hemorrhage with hematoma and a blood pressure of 204/143 mm Hg. A fosphenytoin load infused for seizure prophylaxis and the first dose of a phenytoin maintenance regimen were followed by episodes of hypotension. "
5.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 11/01/2015 - "Safety, Tolerability, and Pharmacokinetics of Fosphenytoin Loading in Patients With Subarachnoid Hemorrhage." 04/01/2010 - "In this prospective, single-center, randomized, single-blinded comparative trial of LEV versus PHT (2:1 ratio) in patients with severe traumatic brain injury (sTBI) or subarachnoid hemorrhage (NCT00618436) patients received IV load with either LEV or fosphenytoin followed by standard IV doses of LEV or PHT. " 11/01/2015 - "Fosphenytoin is frequently used for the rapid delivery of phenytoin in subarachnoid hemorrhage (SAH) patients. "

Related Drugs and Biologics

1.	Phenytoin (Dilantin)
2.	etiracetam (levetiracetam)
3.	Lorazepam (Ativan)
4.	Phenobarbital (Luminal)
5.	Diazepam (Valium)
6.	Benzodiazepines
7.	lacosamide
8.	diphenylhydantoic acid
9.	Valproic Acid (Valproate, Semisodium)
10.	Midazolam (Versed)

Related Therapies and Procedures

1.	Injections
2.	Intramuscular Injections
3.	Intravenous Infusions
4.	Surgical Instruments (Clip)
5.	Length of Stay