17 alpha-iodovinyl-11 beta-methoxyestradiol

RN given refers to 125I-labeled cpd (11beta,17alpha,20E)-isomer; structure given in first source

Also Known As:

11 beta-methoxy-17 alpha-iodovinylestradiol; 11-MIVE; 11-methoxy-17-iodovinyl estradiol; 11-methoxy-17-iodovinylestradiol; IVME2; Z-MIVE; iodine(123)-cis-11beta-methoxy-17alpha-iodovinyl estradiol

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bennink, R J: 1 article (09/2001)
2.	Janssen, A G: 1 article (09/2001)
3.	Noorduyn, L A: 1 article (09/2001)
4.	Rijks, L J: 1 article (09/2001)
5.	Sloof, G W: 1 article (09/2001)
6.	van Tienhoven, G: 1 article (09/2001)
7.	DeSombre, E: 1 article (02/2001)
8.	Hughes, A: 1 article (02/2001)
9.	Yasui, L: 1 article (02/2001)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1998 - "Biodistribution and dosimetry of iodine-123-labelled Z-MIVE: an oestrogen receptor radioligand for breast cancer imaging." 09/01/2001 - "(123)I-labeled Z-MIVE scintigraphy is a sensitive noninvasive tool for the detection of estrogen receptors in patients with breast cancer." 07/01/1997 - "Imaging of estrogen receptors in primary and metastatic breast cancer patients with iodine-123-labeled Z-MIVE." 09/01/2001 - "To determine the sensitivity of iodine 123 ((123)I)-labeled cis-11beta-methoxy-17alpha-iodovinyl estradiol (Z-MIVE) scintigraphy for the detection of estrogen receptors in patients with primary breast carcinoma. " 05/01/1999 - "To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estrogen, E-17alpha-[123I]-iodovinyl-11beta-methoxyestradiol, [123I]IVME2, in vitro. "
2.	Neoplasms (Cancer) 02/01/2001 - "Cell killing in a manner similar to that induced by high-LET radiation and the high RBE for induction of DSBs by (125)IVME2 in the ER-expressing MCF-7 cells provide a biological rationale for the use of Auger electron-emitting radionuclides covalently bound to estrogen to deliver a cytotoxic dose of radiation to ER-positive cancers." 05/01/1999 - "To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estrogen, E-17alpha-[123I]-iodovinyl-11beta-methoxyestradiol, [123I]IVME2, in vitro. "
3.	Neoplasm Micrometastasis 05/01/1999 - "To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estrogen, E-17alpha-[123I]-iodovinyl-11beta-methoxyestradiol, [123I]IVME2, in vitro. "

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Estrogens (Estrogen)
3.	Steroid Receptors (Steroid Receptor)
4.	Radioisotopes (Radionuclides)
5.	Iodine
6.	Estradiol (Delestrogen)

Related Therapies and Procedures

1.	Therapeutics