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SGB 1534

RN given refers to mono-HCl

Also Known As:

3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-(1H,3H)-quinazoline-2,4-dione hydrochloride; SGB-1534

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - SGB 1534: 6

Related Diseases

1.	Stroke (Strokes) 01/01/1988 - "The present study was undertaken to elucidate the effects of a new synthesized phenylpiperazine derivative SGB-1534 on mean arterial blood pressure and heart rate in stroke-prone spontaneously hypertensive rats(SHRSP). " 01/01/1988 - "Effects of SGB-1534, a new synthesized phenylpiperazine derivative, on blood pressure and heart rate in stroke-prone spontaneously hypertensive rats."
2.	Hypotension (Low Blood Pressure) 06/01/1989 - "The result indicates that SGB-1534 may predominantly act upon arterial resistance vessels rather than the venous side, resulting in potent hypotension." 05/01/1987 - "Thus, it seems that SGB-1534, like prazosin, has a balanced effect decreasing afterload as well as preload and that the hypotension is mainly due to the alpha 1-adrenoceptor antagonism in the peripheral vasculatures." 05/01/1989 - "In DOCA-salt hypertensive dogs, persistent hypotension, accompanied by a reflex tachycardia, occurred after oral administration of SGB-1534 and prazosin. "
3.	Tachycardia (Tachyarrhythmias) 05/01/1989 - "In DOCA-salt hypertensive dogs, persistent hypotension, accompanied by a reflex tachycardia, occurred after oral administration of SGB-1534 and prazosin. "
4.	Orthostatic Hypotension (Postural Hypotension) 09/01/1985 - "In an experimental model for determining blood pressure compensation for postural tilt in anesthetized rats, SGB-1534 was free of postural effects, while prazosin induced orthostatic hypotension. "
5.	Heart Failure 08/01/1988 - "Effects of prazosin, dobutamine, isoproterenol and SGB-1534, a new alpha-blockade, on congestive heart failure (CHF) in dogs were investigated. " 08/01/1988 - "[Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs]."

Related Drugs and Biologics

1.	phenylpiperazine
2.	Prazosin (Minipress)
3.	Desoxycorticosterone Acetate (DOCA)
4.	Salts
5.	Isoproterenol (Isoprenaline)
6.	Dobutamine

Related Therapies and Procedures

1.	Oral Administration