kelatorphan

inhibitor of enkephalin metabolism; structure given in first source

Also Known As:

(3-(N-hydroxy)carboxamido-2--benzylpropanoyl)alanine; L-Alanine, N-(4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl)-, (R)-

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - kelatorphan: 6

Experts

1.	Crain, Stanley M: 2 articles (09/2008 - 09/2007)
2.	Shen, Ke-Fei: 2 articles (09/2008 - 09/2007)

Related Diseases

1.	Tremor (Tremors) 04/01/1992 - "Lacrimation and weight loss were reduced by kelatorphan and RB 38 A whereas teeth chattering, tremor, eye twitch and rhinorrhea were decreased only by RB 38 A. " 06/20/1989 - "The rise in plasma corticosterone and the hypothermia were reduced by kelatorphan and RB 38 A whereas rhinorrhea was blocked by thiorphan, tremor by kelatorphan and diarrhoea by RB 38 A. "
2.	Hyperalgesia 09/05/2007 - "Co-treatment with kelatorphan stabilizes putative endogenous opioid peptide agonists released by naloxone in GM1-treated mice, so that analgesia is evoked rather than hyperalgesia. " 09/22/2008 - "Cotreatment with a low subanalgesic dose of kelatorphan, an inhibitor of multiple endogenous opioid peptide-degrading enzymes, stabilizes endogenous opioid agonists released by cAMP-PDE inhibitors, resulting in conversion of the hyperalgesia to analgesia without requiring selective blockade of excitatory opioid receptor signaling. "
3.	Rhinorrhea 04/01/1992 - "Lacrimation and weight loss were reduced by kelatorphan and RB 38 A whereas teeth chattering, tremor, eye twitch and rhinorrhea were decreased only by RB 38 A. " 06/20/1989 - "The rise in plasma corticosterone and the hypothermia were reduced by kelatorphan and RB 38 A whereas rhinorrhea was blocked by thiorphan, tremor by kelatorphan and diarrhoea by RB 38 A. "
4.	Mononeuropathies (Mononeuritis Multiplex) 10/13/1994 - "The antinociceptive effect of i.v. kelatorphan (2.5, 5, 10 and 15 mg/kg), a mixed inhibitor of enkephalin degrading enzymes, was studied in a rat model of peripheral unilateral mononeuropathy (chronic constriction of the common sciatic nerve). "
5.	Weight Loss (Weight Reduction) 04/01/1992 - "Lacrimation and weight loss were reduced by kelatorphan and RB 38 A whereas teeth chattering, tremor, eye twitch and rhinorrhea were decreased only by RB 38 A. "

Related Drugs and Biologics

1.	Enzymes
2.	Opioid Peptides (Opioid Peptide)
3.	Enkephalins
4.	3- (N- hydroxycarboxamido- 2- benzylpropanoyl)phenylalanine
5.	Thiorphan
6.	Opioid Receptors (Opioid Receptor)
7.	Naloxone (Narcan)
8.	Freund's Adjuvant
9.	Corticosterone
10.	Opioid Analgesics (Opioids)

Related Therapies and Procedures

1.	Analgesia