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ZK 93423
Also Known As:
6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester; ZK 93 423; ZK-93423
Networked:
11
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Carbolines: 283
ZK 93423: 11
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Carbolines: 283
ZK 93423: 11
3-Ring Heterocyclic Compounds
Carbolines: 283
ZK 93423: 11
Related Diseases
1.
Seizures (Absence Seizure)
11/17/1987 - "
This study examined the effects of chronic treatment with the benzodiazepine clonazepam and the beta-carboline ZK 93423 (6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester), a full agonist at brain benzodiazepine receptors, on amygdala-kindled seizures in rats.
"
09/01/1987 - "
Derivatives of ethyl-beta-carboline-3-carboxylate, ZK 91296, ZK 93423 and ZK 95962 have potent anticonvulsant activity against sound-induced seizures in audiogenic DBA/2 mice and against photically-induced seizures in the baboon, Papio papio.
"
01/01/1990 - "
The benzodiazepine receptor agonist beta-carboline ZK 93423 blocked convulsions induced by kainate but had no effect on seizures induced by N-methyl-D-aspartate or quisqualate.
"
2.
Hypothermia
08/28/1990 - "
The benzodiazepine full agonist loprazolam and the beta-carboline ZK 93423 produced hypothermia in mice (1-30 mg/kg i.p.).
"
05/12/1993 - "
Pretreatment with flumazenil (30 mg/kg) completely blocked the hypothermia produced by flurazepam (30 mg/kg), zolpidem (3 mg/kg), and FG 7142 (60 mg/kg), only partially reversed ZK 93423 (3 mg/kg), and was ineffective against 10 mg/kg zolpidem.
"
05/12/1993 - "
The benzodiazepine receptor agonists, flurazepam, zolpidem, ZK 93423, and the benzodiazepine inverse agonist, FG 7142, all produced hypothermia when injected i.p.
"
3.
Epilepsy (Aura)
11/17/1987 - "
The data indicate that, compared to benzodiazepines, the beta-carboline ZK 93423 has no advantage in terms of anticonvulsant potency, side-effects and development of tolerance in the amygdala kindling model of epilepsy.
"
08/27/1985 - "
Three benzodiazepine (BZ) receptor ligands of the beta-carboline group, namely the BZ receptor agonist ZK 93 423, the partial agonist ZK 91 296, and the antagonist ZK 93 426, were studied in epilepsy-prone Mongolian gerbils with different seizure types.
"
4.
Shock
02/24/1987 - "
ZK 93423, a recently synthesized beta-carboline with benzodiazepine-like properties, prevented the decrease in DA content induced by foot-shock at the dose of 20 mg/kg. Moreover, the stress-induced increase in DOPAC levels was partly or completely blocked by pretreatment with 20 or 40 mg/kg of ZK 93423, respectively.
"
5.
Myoclonus (Nocturnal Myoclonus)
06/29/1984 - "
ZK 91296 and ZK 93423, suppress myoclonus with a potency at least as great as diazepam.
"
Related Drugs and Biologics
1.
norharman
2.
GABA-A Receptors (GABA(A) Receptor)
3.
Benzodiazepines
4.
Clonazepam (Rivotril)
5.
ZK 91296
6.
Anticonvulsants (Antiepileptic Drugs)
7.
Quisqualic Acid
8.
N-Methylaspartate (NMDA)
9.
3,4-Dihydroxyphenylacetic Acid
10.
Lorazepam (Ativan)