dopachrome isomerase

decarboxylates & converts dopachrome to 5,6-dihydroxyindole; does not convert the latter to indole-5,6-quinone; a melanoma-associated antigen; found in human & mouse hairbulbs; RefSeq NM_001922 (human), NM_010024 (mouse)
Also Known As:
3,4-dihydroxyphenylalaninechrome tautomerase; DCT protein, human; Dct protein, mouse; TRP-2 protein, tyrosinase-related; TRP2 protein, mouse; TYRP2 protein, human; Tyrosinase-related protein 2, human; Tyrp2 protein, mouse; dopachrome conversion factor; dopachrome oxidoreductase; dopachrome tautomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), human; slaty protein, mouse; tyrosinase-related protein-2; tyrosinase-related protein-2, mouse
Networked: 97 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Wan, Yonghong: 4 articles (06/2010 - 07/2007)
2. Mitchell, Robert A: 3 articles (11/2012 - 08/2008)
3. Rendon, Beatriz E: 3 articles (11/2012 - 08/2008)
4. Bramson, Jonathan L: 3 articles (06/2010 - 10/2009)
5. Hoon, Dave S B: 3 articles (12/2006 - 10/2003)
6. Craft, Noah: 3 articles (01/2006 - 07/2005)
7. Miller, Jeff F: 3 articles (01/2006 - 07/2005)
8. Bruhn, Kevin W: 3 articles (01/2006 - 07/2005)
9. Petrescu, Stefana M: 2 articles (06/2014 - 03/2005)
10. Negroiu, Gabriela: 2 articles (06/2014 - 03/2005)

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Experimental Melanoma
3. Neoplasms (Cancer)
4. Glioblastoma (Glioblastoma Multiforme)
5. Oculocutaneous Albinism (Albinism, Yellow Mutant)
01/01/2011 - "Four genes (oculocutaneous albinism II (OCA2), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT), and KIT ligand (KITLG)) implicated in human skin-color variation, have shown evidence for positive selection in Europeans and East Asians in previous SNP-scan data. "
01/01/2014 - "The sum of these findings suggests that reduced glutathione selectively disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization, probably serving as a putative model for oculocutaneous albinism type 4. "
01/01/2015 - "Serum 25(OH)D and SNPs (n = 960) related to genes with relevance for skin pigmentation (tyrosinase [TYR], TYR-related protein 1 [TYRP1], dopachrome tautomerase [DCT], oculocutaneous albinism II [OCA2], two pore segment channel 2 [TPCN2], solute carrier family 24 A4 [SLC24A4], solute carrier family 45 A2 [SLC45A2], agouti signalling peptide [ASIP], cyclic AMP-dependent transcription factor [ATF1], microphthalmia-associated transcription factor [MITF], proopiomelanocortin [POMC], cAMP-dependent protein kinase catalytic subunit beta [PRKACB], cAMP-dependent protein kinase catalytic subunit gamma [PRKACG], cAMP-dependent protein kinase type I-alpha regulatory subunit [PRKAR1A], cAMP-dependent protein kinase type II-alpha regulatory subunit [PRKAR2A], cAMP-dependent protein kinase type II-beta regulatory subunit [PRKAR2B], tubulin beta-3 chain/melanocortin receptor 1 [TUBB3/MC1R], Cadherin-1 [CDH1], catenin beta 1 [CTNNB1], Endothelin 1 [EDN1], endothelin 3 [EDN3], endothelin receptor type B [EDNRB], fibroblast growth factor 2 [FGF2], KIT, KIT ligand [KITLG], nerve growth factor [NGF], interferon regulatory factor 4 [IRF4], exocyst complex component 2 [EXOC2], and tumor protein 53 [TP53]) were analyzed in a cohort of participants of the Ludwigshafen Risk and Cardiovascular Health Study (n = 2970). "

Related Drugs and Biologics

1. Antigens
2. A-Form DNA (A-DNA)
3. Monophenol Monooxygenase (Tyrosinase)
4. Microphthalmia-Associated Transcription Factor
5. tyrosinase-related protein-1
6. Stem Cell Factor
7. Type 1 Melanocortin Receptor
8. Endothelin-3 (Endothelin 3)
9. Pro-Opiomelanocortin (Proopiomelanocortin)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Immunotherapy
2. Ligation