alpha-methylserotonin

potent agonist at M & D receptors of serotonin; RN given refers to parent cpd

Also Known As:

alpha-methyl-5-HT; alpha-methyl-5-HT maleate; alpha-methyl-5-hydroxytryptamine; alpha-methylserotonin, (Z)-2-butenedioate

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Biogenic Amines: 992
    - Biogenic Monoamines: 29
      - Tryptamines: 1679
        Serotonin: 21125
        alpha-methylserotonin: 15
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        Serotonin: 21125
        alpha-methylserotonin: 15
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Serotonin: 21125
      - alpha-methylserotonin: 15

Experts

1.	Goto, Fumio: 2 articles (03/2004 - 04/2003)
2.	Obata, Hideaki: 2 articles (03/2004 - 04/2003)
3.	Saito, Shigeru: 2 articles (03/2004 - 04/2003)
4.	Sasaki, Masayuki: 2 articles (03/2004 - 04/2003)
5.	Gilmour, Kathleen M: 1 article (01/2010)
6.	McDonald, M Danielle: 1 article (01/2010)
7.	Perry, Steve F: 1 article (01/2010)
8.	Walsh, Patrick J: 1 article (01/2010)
9.	Clark, Michael G: 1 article (06/2009)
10.	Dwyer, Renee M: 1 article (06/2009)

Related Diseases

1.	Insulin Resistance 06/01/2009 - "The aim of this study was to determine the effect of acute insulin resistance caused by the peripheral vasoconstrictor alpha-methylserotonin (alphaMT) on microvascular vasomotion in muscle. "
2.	Pain (Aches) 04/01/2003 - "Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain." 04/22/1996 - "Neither of these agents altered pain produced by alpha-methyl-5-HT plus prostaglandin E2 (0.1 microgram). " 04/22/1996 - "Thus, activation of alpha 1A-adrenoceptors can contribute to pain, but pain induced by alpha-methyl-5-HT plus prostaglandin E2 is independent of adrenergic function, indicating that adrenergic function is not necessary for induction of pain by inflammatory mediators. " 04/22/1996 - "Phenylepherine, but not clonidine, substituted for noradrenaline to induce pain when combined with alpha-methyl-5-HT. " 04/22/1996 - "Contribution of peripheral alpha 1A-adrenoceptors to pain induced by formalin or by alpha-methyl-5-hydroxytryptamine plus noradrenaline."
3.	Bradycardia 11/01/1994 - "Alpha-methyl-5-HT (10-300 micrograms/kg i.v.) dose-dependently increased MAP, TPR, all regional vascular resistances and decreased CO and HR. The bradycardia induced by alpha-methyl-5-HT was suppressed by bivagotomy. " 01/31/2010 - "Injection of alpha-methyl-5-HT, a 5-HT(2) agonist, also resulted in bradycardia that was inhibited by ketanserin, lending further support for 5-HT(2) receptor involvement, possibly 5-HT(2A) or 5-HT(2C), in the regulation of fH. " 11/01/2007 - "4. Vagally induced bradycardia in diabetic rats was not affected by administration of the selective 5-HT(2) receptor agonist alpha-methyl-5-HT (150 microg/kg), the selective 5-HT(3) receptor agonist 1-phenylbiguanide (150 microg/kg) or the selective 5-HT(1B) receptor agonist CGS-12066B (50 microg/kg). "
4.	Hyperphagia (Overeating) 12/01/2000 - "These results suggest that NO is differentially related to alpha-methyl-5-HT and 5-CT-induced hypophagia and that NO may play a role in hypo- and hyperphagia." 11/28/1996 - "alpha-Methyl-5-HT also inhibited 2-deoxy-D-glucose-induced hyperphagia in rats. "
5.	Vomiting 03/01/1995 - "2. alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT), a peripheral 5-HT2A/5-HT2C receptor agonist, had no effect on motion- and cisplatin-induced emesis. "

Related Drugs and Biologics

1.	Vasoconstrictor Agents
2.	Dinoprostone (PGE2)
3.	Serotonin (5 Hydroxytryptamine)
4.	Ketanserin
5.	Spiperone
6.	2-methyl-5-HT
7.	Serotonin 5-HT2 Receptor Antagonists
8.	5-HT2C Serotonin Receptor
9.	5-HT1B Serotonin Receptor
10.	Idazoxan

Related Therapies and Procedures

1.	Aftercare (After-Treatment)