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phenoxy radical

Also Known As:

phenol ion; phenoxy ion; phenoxyl radical

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        phenoxy radical: 7

Experts

1.	Giorgianni, Angela: 2 articles (03/2011 - 07/2006)
2.	Yalowich, Jack C: 2 articles (03/2011 - 07/2006)
3.	Basarić, Nikola: 1 article (01/2017)
4.	Bohne, Cornelia: 1 article (01/2017)
5.	Kralj, Marijeta: 1 article (01/2017)
6.	Martin Kleiner, Irena: 1 article (01/2017)
7.	Mlinarić-Majerski, Kata: 1 article (01/2017)
8.	Oake, Jessy: 1 article (01/2017)
9.	Wan, Peter: 1 article (01/2017)
10.	Škalamera, Đani: 1 article (01/2017)

Related Diseases

1.	Myeloid Leukemia (Leukemia, Myelocytic) 03/01/2011 - "Previous studies demonstrated that the phenoxyl radical of etoposide can be produced by action of myeloperoxidase (MPO), an enzyme found in developing myeloid progenitor cells, the likely origin for myeloid leukemias. " 07/01/2006 - "Previous studies showed that the phenoxyl radical of etoposide can be generated by myeloperoxidase (MPO), an enzyme prevalent in myeloid progenitor cells that can derive myelogenous leukemias. "
2.	Cardiotoxicity 11/21/1995 - "VP-16 phenoxyl radical-induced oxidation of sulfhydryls and inhibition of the Na+/K(+)-ATPase may be responsible for at least some of its clinical side effects (e.g., cardiotoxicity) which can be prevented by ascorbate."
3.	Carcinogenesis 09/01/2004 - "These findings suggest a role for the OTA phenoxyl radical in OTA-mediated DNA adduction in vivo, provide a rationale for the tumorigenesis of OTA, and strengthen the OTA hypothesis in the etiology of BEN and the associated urinary tract tumors."
4.	Neoplasms (Cancer) 09/01/2004 - "These findings suggest a role for the OTA phenoxyl radical in OTA-mediated DNA adduction in vivo, provide a rationale for the tumorigenesis of OTA, and strengthen the OTA hypothesis in the etiology of BEN and the associated urinary tract tumors."
5.	Necrosis 09/15/2010 - "The cytotoxic mechanism comprises a reaction of Trolox with photo-decomposition products of nitrite, which leads to increased Trolox phenoxyl radical formation, increased intracellular oxidative stress, and a consecutive induction of apoptosis and necrosis in fast proliferating T cells. "

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Peroxidase (Myeloperoxidase)
3.	Enzymes
4.	Phenol (Carbolic Acid)
5.	Nitrites
6.	Flavonoids
7.	DNA (Deoxyribonucleic Acid)
8.	Cations
9.	Adenosine Triphosphatases (ATPase)
10.	hydroxide ion