complement C5b-8 complex

the complement complex containing C5b, C6, C7, and C8; generated during the cascade of complement activation; it catalyzed the assembly of poly-C9 to form the MEMBRANE ATTACK COMPLEX or C5b-p9.

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Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gilbert, Robert J C: 1 article (01/2010)

Related Diseases

1.	Hemolysis 11/01/1980 - "The availability of serum totally lacking in C9 permitted an investigation of the lytic capacity of the C5b-8 segment of the C attack mechanism, which was pursued in kinetic studies on the hemolysis of erythrocyte intermediates. " 07/12/1988 - "Inhibition of hemolysis is not caused by blocking of C9 binding to the C5b-8 complex; rather the antibody must dissociate from the bound C9 before lysis ensues, indicating that it interferes with a postbinding event. " 07/03/1984 - "Time-based measurements of the fluorescence change observed during incubation of FITC-C9 with C5b-8-treated sheep red blood cell ghost membranes at various temperatures revealed that C9 polymerization induced by the C5b-8 proteins exhibits a temperature dependence similar to that previously reported for the complement-mediated hemolysis of these cells, with an Arrhenius activation energy for FITC-C9 polymerization of 13.3 +/- 3.2 kcal mol-1 (mean +/- 2 SD). "
2.	Demyelinating Diseases (Demyelinating Disease) 08/01/1983 - "Extensive demyelination was observed in C8-reconstituted cultures whereas antibody + C8D-HS did not demyelinate, indicating the essential requirement of C5b-8, and/or C5b-9. " 08/01/1992 - "Complement activation to produce channel-forming terminal complement complexes, C5b-8 and C5b-9, was required for demyelination in vitro. "
3.	Inflammation (Inflammations) 05/01/1997 - "Assembly of terminal complement complexes (TCC) C5b-7, C5b-8, and C5b-9 on target cells during acute and chronic inflammation induces hydrolysis of plasma membrane phospholipids and heterotrimeric G protein activation. "
4.	AIDS-Related Complex (ARC) 01/01/2010 - "Complement acts by a combination of the C5b-8 complex of proteins preassembled on a target membrane recruiting C9 to form a lesion, which may be a complete ring of C9 associated with the C5b-8 or an arc-electron microscopy images show both possibilities.Perforin"

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Complement Membrane Attack Complex (Membrane Attack Complex)
3.	Proteins (Proteins, Gene)
4.	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)
5.	Phospholipids (Phosphatides)
6.	complement C5b-7 complex