ADEKO

05/01/1991 - "ADEKO damages preferentially tumor cells as compared to bone marrow."
05/01/1991 - "Chromosomal aberrations induced by the drug are observed in the tumor long after the action of the drug and their level correlates positively with antitumor activity of ADEKO. "
01/01/1984 - "The synergism of the therapeutic action shown in a combined application of ADEKO and cyclophosphamide was stipulated by the potentiation of the lethal effect of these drugs on tumor cells."
07/01/1998 - "After late administration (11 days after tumor transplantation), NMM was most effective at increasing survival (35% of survived animals by 35 days of observation), while the rate of tumor regression increased in the sequence ADEKO < NMM < karmustin < nitrulin < ACNU."
05/01/1996 - "Simultaneous introduction of cytostatic drugs (cyclophosphamide, dimethylnitrosourea, ADEKO) and Dibunol to tumor carriers was efficient and increased the mean life span of animals. "

01/01/1986 - "An antitumour activity of combined application of two nitrosomethylurea derivatives--dimethylnitrosourea and ADEKO with cytostatics of various groups was studied in transplanted tumours of La and L 1210 leukemias and Lewis lung carcinoma. "

07/01/1998 - "We studied the sensitivity of human melanoma (Bro strain) xenografts to drugs of the nitrosoalkylurea (NAU) class: nitrosomethylurea (NMM), karmustin (BCNU), nimustin (ACNU), nitrulin, and ADEKO. "

01/01/1986 - "An antitumour activity of combined application of two nitrosomethylurea derivatives--dimethylnitrosourea and ADEKO with cytostatics of various groups was studied in transplanted tumours of La and L 1210 leukemias and Lewis lung carcinoma. "

05/01/1991 - "Chromosomal aberrations induced by the drug are observed in the tumor long after the action of the drug and their level correlates positively with antitumor activity of ADEKO. "