DNA reverse gyrase

An atypical topoisomerase found in hyperthermophilic microorganisms, such as archaea and hyperthermophilic eubacteria. Reverse gyrase is able to positively supercoil DNA in the presence of ATP as helicases. In recent literature, it is classified as one of the Type I DNA topoisomerases (including topoisomerase I, III, V, and reverse gyrase). Previously, this enzyme was indexed under DNA Topoisomerase (ATP-Hydrolysing), a Type II DNA topoisomerase.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ciaramella, Maria: 4 articles (09/2014 - 02/2009)
2.	Perugino, Giuseppe: 4 articles (09/2014 - 02/2009)
3.	Rossi, Mosè: 4 articles (09/2014 - 02/2009)
4.	Valenti, Anna: 4 articles (09/2014 - 02/2009)
5.	Nadal, Marc: 2 articles (08/2012 - 04/2007)
6.	Feng, Xu: 1 article (06/2017)
7.	Han, Wenyuan: 1 article (06/2017)
8.	She, Qunxin: 1 article (06/2017)
9.	Vettone, Antonella: 1 article (09/2014)
10.	Akhtar, Muhammad: 1 article (02/2014)

Related Diseases

1.

Genomic Instability 02/07/2014 - "Our results suggest for the first time that a reverse gyrase shares not only structural but also functional features with evolutionary conserved helicase-topoisomerase complexes involved in genome stability. " 02/01/2009 - "Reverse gyrase and genome stability in hyperthermophilic organisms." 04/01/2007 - "Moreover, it has been proposed that reverse gyrase has been implicated in genome stability." 06/22/2017 - "Reverse gyrase introduces positive supercoils to circular DNA and is implicated in genome stability maintenance in thermophiles. " 09/01/2014 - "Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase."

Related Drugs and Biologics

1.	Enzymes
2.	Circular DNA
3.	DNA (Deoxyribonucleic Acid)
4.	DNA alkyltransferase