HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

nitazoxanide (NTZ)

Subscribe to New Research on nitazoxanide

a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug; structure given in first source

Also Known As:

NTZ; Alinia; Daxon; Colufase; Columbia Brand 1 of Nitazoxanide; Columbia Brand 2 of Nitazoxanide; Columbia Brand 3 of Nitazoxanide; Cryptaz; Heliton; Romark Brand 1 of Nitazoxanide; Romark Brand 2 of Nitazoxanide; Solvay Brand of Nitazoxanide; Taenitaz; Unimed Brand of Nitazoxanide; 2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide

Networked: 210 relevant articles (61 outcomes, 46 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rossignol, Jean-François: 16 articles (10/2014 - 10/2005)
2.	Hoffman, Paul S: 5 articles (08/2014 - 03/2002)
3.	Hemphill, Andrew: 5 articles (10/2011 - 01/2006)
4.	Favennec, L: 5 articles (02/2006 - 06/2001)
5.	Gargala, G: 5 articles (02/2006 - 06/2001)
6.	Guerrant, Richard L: 4 articles (08/2014 - 12/2011)
7.	Müller, Joachim: 4 articles (08/2013 - 01/2006)
8.	Keeffe, Emmet B: 4 articles (08/2010 - 10/2008)
9.	Musher, Daniel M: 4 articles (02/2009 - 08/2006)
10.	Rossignol, J F: 4 articles (09/2008 - 07/2001)

Related Diseases

1.	Infection 02/01/2007 - "The increase in CD3+/CD4+ cells secondary to the reduction of steroid therapy associated with the improvement of aGvHD and the use of antiparasitic treatments (especially nitazoxanide) improved the infection-related symptoms and led to a complete clearance of the Cryptosporidium." 02/01/2015 - "NTZ was effective against all IAVs tested, with 50% inhibitory concentrations (IC50s) ranging from 0.9 to 3.2 μM, and selectivity indexes (SIs) ranging from >50 to >160, depending on the strain and the multiplicity of infection (MOI). " 01/01/2014 - "Prompt resolution of diarrhoea without adverse outcomes suggests nitazoxanide may be an effective treatment for Cryptosporidium infection in this setting. " 08/01/2013 - "NTZ was effective in the treatment of Cryptosporidium infection, with a greater effect in group III than in group IV. C. " 01/01/2007 - "Nitazoxanide is effective in the treatment of protozoal and helminthic infections, including Cryptosporidium parvum or Giardia lamblia, in immunocompetent adults and children, and is generally well tolerated. "
2.	Cryptosporidiosis 02/01/2004 - "Nitazoxanide is the first agent proven to be effective in cryptosporidiosis. " 01/01/2009 - "We hypothesised that a prolonged course of treatment with high dose nitazoxanide would be effective in treating cryptosporidiosis in HIV positive Zambian children. " 06/01/2012 - "Nitazoxanide was shown to be effective for cryptosporidiosis in the 1990s." 12/01/2004 - "Nitazoxanide is effective for cryptosporidiosis in immunocompetent and probably immunocompromised patients (with an alteration in the duration of treatment or the dosing regimen). " 12/01/2007 - "Efficacy of nitazoxanide against experimental cryptosporidiosis in goat neonates."
3.	Diarrhea 08/01/2013 - "Significant improvement and shortening of the duration of diarrhea occur in G1; of 45 patients received Nitazoxanide 39 cases showed complete clinical and laboratory cure (86.6%), 5 cases showed clinical improvement with reduction in the number of oocysts and 1 case showed no cure. " 08/01/2001 - "With its efficacy in treating a broad spectrum of enteric protozoan pathogens, nitazoxanide could play an important role in the management of diarrhea caused by enteric protozoa, reducing morbidity and costs associated with these diarrheal illnesses." 08/01/2006 - "Nitazoxanide has high efficacy against Cryptosporodial diarrhea only. " 08/01/1998 - "However, the higher dose of NTZ induced a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy. " 07/01/2009 - "Treatment with nitazoxanide and probiotics is effective in the management of children with acute rotavirus diarrhea. "
4.	Chronic Hepatitis C 09/01/2008 - "To evaluate the safety and efficacy of nitazoxanide monotherapy for the treatment of chronic hepatitis C. " 01/01/2016 - "A total of 200 patients with chronic hepatitis C were enrolled in the study, assigned randomly in a 1 : 1 ratio to two groups: group A (placebo group) and group B (nitazoxanide group). " 01/01/2016 - "Impact of nitazoxanide on sustained virologic response in Egyptian patients with chronic hepatitis C genotype 4: a double-blind placebo-controlled trial." 01/01/2014 - "More randomised clinical trials with a low risk of bias are needed to assess the effects of nitazoxanide for chronic hepatitis C." 01/01/2014 - "We included randomised clinical trials that examined the effects of nitazoxanide versus placebo, no intervention, or any other intervention in patients with chronic hepatitis C. "
5.	Acquired Immunodeficiency Syndrome (AIDS) 03/15/2005 - "Nitazoxanide given orally for 14 days was associated with clinical improvement in Zambian acquired immune deficiency syndrome patients with diarrhoea, especially those with very low CD4 counts." 06/01/1997 - " Nitazoxanide was also effective against other parasites common in AIDS patients, including Entamoeba histolytica, Giardia lamblia, and Isospora belli. " 05/01/2003 - "Nitazoxanide is a new treatment option for blastocystosis in AIDS patients. " 11/01/1998 - "A double-'blind' placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in AIDS patients in Mexico." 04/01/2013 - "Nitazoxanide, the current standard of care, has limited efficacy in children and is no more effective than placebo in patients with advanced AIDS. "

Related Drugs and Biologics

1.	nitazoxanide (NTZ)
2.	Ribavirin (Virazole)
3.	Albendazole (Albenza)
4.	natalizumab (Tysabri)
5.	Paromomycin (Paromomycin Sulfate)
6.	tizoxanide
7.	Interferons
8.	Mebendazole (Vermin)
9.	Praziquantel (Biltricide)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Intraperitoneal Injections
3.	Immunotherapy
4.	Drug Repositioning
5.	Aftercare (After-Treatment)