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beta-D-aspartylaminomethylphosphonic acid (Asp-Amp)
Also Known As:
Asp-Amp
; beta-D-aspartylaminomethylphosphonate; D-Asparagine, N-(phosphonomethyl)-, (R*,R*)-(-)-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Excitatory Amino Acids: 1301
Aspartic Acid: 3444
beta-D-aspartylaminomethylphosphonic acid: 4
Acidic Amino Acids: 44
Aspartic Acid: 3444
beta-D-aspartylaminomethylphosphonic acid: 4
Dicarboxylic Amino Acids: 20
Aspartic Acid: 3444
beta-D-aspartylaminomethylphosphonic acid: 4
Related Diseases
1.
Seizures (Absence Seizure)
06/26/1987 - "
Asp-Amp also significantly increases the onset pressures for myoclonus and for tonic-clonic seizures.
"
03/23/1984 - "
Two new phosphonate dipeptides, gamma-D- glutamylaminomethylphosphonate (Glu-Amp) and beta-D- aspartylaminomethylphosphonate (Asp-Amp), that are antagonists of excitation due to N-methyl-D-aspartate have been compared with omega-phosphonic-alpha-carboxylic amino acids as anticonvulsant agents in mice with sound-induced seizures.
"
2.
Tremor (Tremors)
06/26/1987 - "
Intracerebroventricular injection in the rat of beta-D-aspartyl aminomethylphosphonate (Asp-Amp) 1 mumol, or Y-D-glutamylaminomethylsulphonate (GAMS) 1 mumol, increases the onset pressure for the initial tremor phase of the high pressure neurological syndrome (HPNS) by 50%.
"
3.
Myoclonus (Nocturnal Myoclonus)
06/26/1987 - "
Asp-Amp also significantly increases the onset pressures for myoclonus and for tonic-clonic seizures.
"
4.
High Pressure Neurological Syndrome (High Pressure Nervous Syndrome)
06/26/1987 - "
Intracerebroventricular injection in the rat of beta-D-aspartyl aminomethylphosphonate (Asp-Amp) 1 mumol, or Y-D-glutamylaminomethylsulphonate (GAMS) 1 mumol, increases the onset pressure for the initial tremor phase of the high pressure neurological syndrome (HPNS) by 50%.
"
5.
Catalepsy
09/01/1987 - "
The rank order of potency to produce catalepsy was AP7 greater than D-AP5 greater than D,L-AP5 greater than cis-PDA greater than ASP-AMP greater than AP4 greater than L-AP5 greater than GAMS; there was a strong positive correlation between this rank order of potency in vivo and the potency order of these compounds in vitro as NMDA antagonists.
"
09/01/1987 - "
The excitatory amino acid antagonists D,L-2-amino-5-phosphonovalerate (D,L-AP5), its isomers D-(-)-AP5 and L-(+)-AP5, D,L-2-amino-4-phosphonobutyrate (AP4), D,L-2-amino-7-phosphonoheptanoate (AP7), beta-D-aspartylaminomethylphosphonic acid (ASP-AMP), cis-2,3-piperidinedicarboxylic acid (cis-PDA), and gamma-D-glutamylaminomethylsulphonic acid (GAMS) were tested for their ability to produce a phencyclidine (PCP)-like catalepsy in pigeons when administered intracerebroventricularly.
"
Related Drugs and Biologics
1.
beta-D-aspartylaminomethylphosphonic acid (Asp-Amp)
2.
N-Methylaspartate (NMDA)
3.
gamma-glutamylaminomethylsulfonic acid (GAMS)
4.
Organophosphonates (Phosphonates)
5.
Excitatory Amino Acid Antagonists
6.
Phencyclidine (Angel Dust)
7.
Dipeptides
8.
Bilirubin
9.
Anticonvulsants (Antiepileptic Drugs)
10.
Transaminases (Aminotransferases)
Related Therapies and Procedures
1.
Hepatectomy