cinchonidine

has antimalarial activity; diastereoisomer of cinchonine with distinct physiochemical properties; RN given refers to parent cpd(8alpha,9R)-isomer

Also Known As:

2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-; cinchonidine hydrochloride; cinchonidine monohydrochloride; cinchonidine sulfate(2:1); cinchonidine, (1beta,3alpha,4beta,8alpha,9R)-isomer; (8-alpha,9R)-Cinchonan-9-ol

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Cinchona Alkaloids: 29
    - cinchonidine: 11

Experts

1.	Borgatti, Monica: 1 article (12/2021)
2.	Cosenza, Lucia Carmela: 1 article (12/2021)
3.	Finotti, Alessia: 1 article (12/2021)
4.	Gambari, Roberto: 1 article (12/2021)
5.	Lampronti, Ilaria: 1 article (12/2021)
6.	Scapoli, Chiara: 1 article (12/2021)
7.	Zuccato, Cristina: 1 article (12/2021)
8.	Zurlo, Matteo: 1 article (12/2021)
9.	Badria, Farid A: 1 article (08/2021)
10.	El-Dosoky, Mohamed: 1 article (08/2021)

Related Diseases

1.	Malaria 01/01/1920 - "Cinchonidine in Malaria." 09/01/1899 - "Cinchonidine and Wrightia Antidysenterica as Prophylactics against Dysentery and Malaria." 01/01/2016 - "The analytical part will supplement knowledge about quinidine, quinine, and cinchonidine, and will contribute to the growth of research on the so-much-needed drugs against malaria. " 11/01/2004 - "The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine (Quinimax) was compared to that of parenteral regimens in 60 children with moderate malaria. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2018 - "Five cinchonidine derivatives displayed 95-510 times higher inhibition selectivity to butyrylcholinesterase over acetylcholinesterase and four were potent butyrylcholinesterase inhibitors with Ki constants up to 100 nM, of which N-para-bromobenzyl cinchonidinium bromide can be considered a lead for further modifications and optimizations for possible use in the treatment of neurodegenerative diseases."
3.	Thalassemia 12/14/2021 - "The data obtained demonstrate that cinchonidine and quinidine are potent inducers of γ-globin mRNA and HbF in erythroid progenitor cells isolated from nine β-thalassemia patients. " 12/14/2021 - "After an initial analysis using the K562 cell line as an experimental model system, showing induction of hemoglobin and γ-globin mRNA, we verified whether the two more active compounds, cinchonidine and quinidine, were able to induce HbF in erythroid progenitor cells isolated from β-thalassemia patients. "
4.	Sarcoma (Soft Tissue Sarcoma) 10/01/2020 - "Then we also used the CMap online tool to screen five targeted drugs (rilmenidine, pizotifen, amiprilose, quipazine, and cinchonidine) for this risk score model in sarcoma. "
5.	Neoplasms (Cancer) 08/01/2021 - "The ability of quinoline alkaloids (cinchonine, cinchonidine, quinine, and quinidine) to sensitize different human cancer cell lines to doxorubicin (DOX)-induced cell death was evaluated. "

Related Drugs and Biologics

1.	Quinidine (Chinidin)
2.	Quinine (Quinson)
3.	cinchonine
4.	Alkaloids
5.	Thiourea
6.	Messenger RNA (mRNA)
7.	Quipazine
8.	Pizotyline (BC 105)
9.	Hydrochloric Acid (Hydrogen Chloride)
10.	Hemoglobins (Hemoglobin)