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mioflazine

Also Known As:

R 51 469; R 51469; R-51469

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - mioflazine: 7

Related Diseases

1.	Parasitic Diseases (Parasitic Disease) 05/01/1990 - "Present data indicate that mioflazine and its derivatives are not very potent in some of the preferred animal models for parasitic infections (mouse, hamster) but are more effective in primates such as man and baboon."
2.	Infarction (Infarctions) 01/01/1985 - "The effects of oral pretreatment with mioflazine (2.5 mg X kg-1) on regional myocardial reflow, infarct size reduction and hemodynamic recovery were studied in 24 anesthetized open-chest dogs undergoing 90 minutes of acute left anterior descending coronary artery (LAD) occlusion followed by 150 minutes of reperfusion. " 04/01/1984 - "For perfusion areas greater than 20% of the left ventricle infarct size was significantly reduced in mioflazine pretreated animals compared with the control group, both expressed as per cent of the left ventricle (10.6 +/- 2.3 vs 19.2 +/- 1.5, p less than 0.005) and as per cent of the perfusion area (35.1 +/- 7 vs 64.4 +/- 5, p less than 0.005)." 01/01/1985 - "It is concluded that pretreatment with mioflazine prevents the no-reflow phenomenon after reperfusion of an evolving infarction, tends to reduce infarct size and improves hemodynamic recovery." 04/01/1984 - "The effect of mioflazine (R 51 469) on infarct size was studied in anesthetized dogs subjected to 24 h of LAD (left anterior descending) coronary artery occlusion. "
3.	Hypoxia (Hypoxemia) 02/01/1994 - "This pattern, which was observed when purine release was induced both by electrical field stimulation and by hypoxia/hypoglycemia, was shared by the nucleoside transport inhibitor dipyridamole (1 microM) and by mioflazine (1 microM) and nitrobenzylthioinosine (1 microM). " 09/01/1983 - "Lidoflazine, flunarizine, and R 51 469 antagonized contractions of isolated canine coronary arteries caused by depolarizing solution or 5-hydroxytryptamine, and the further increase in tension caused by hypoxia during such contractions. "
4.	No-Reflow Phenomenon 01/01/1985 - "In the animals pretreated with mioflazine (n = 12) the hyperemic response persisted throughout the reperfusion phase and the no-reflow phenomenon was prevented. " 01/01/1985 - "Prevention of the "no reflow" phenomenon in the canine heart by mioflazine." 01/01/1985 - "It is concluded that pretreatment with mioflazine prevents the no-reflow phenomenon after reperfusion of an evolving infarction, tends to reduce infarct size and improves hemodynamic recovery."
5.	Sleep Wake Disorders 01/01/1987 - "Mioflazine might be the prototype of substances worth considering for the treatment of a variety of sleep disorders."

Related Drugs and Biologics

1.	Nucleosides
2.	mioflazine
3.	Solutions
4.	Serotonin (5 Hydroxytryptamine)
5.	Lidoflazine
6.	Inosine
7.	Flunarizine
8.	Dipyridamole (Persantine)
9.	Adenosine (Adenocard)
10.	purine