interstitial retinol-binding protein

binds several retinoids; contains sialic acid, neutral hexoses & glucosamine; do not confuse with inverted repeat binding protein (also known as IRBP)

Also Known As:

IRBP protein, human; IRBP protein, mouse; RBP3 protein, human; RBPI protein, human; Rbp3 protein, mouse; interphotoreceptor retinoid-binding protein; interphotoreceptor retinoid-binding protein, human; interphotoreceptor retinoid-binding protein, mouse; interphotoreceptor retinol-binding protein; interstitial retinol-binding protein, human; interstitial retinol-binding protein, mouse; retinal A-antigen; retinol binding protein 3, interstitial, human

Networked: 187 relevant articles (3 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Retinol-Binding Proteins: 1400
      - interstitial retinol-binding protein: 187
  - Eye Proteins: 2
    - interstitial retinol-binding protein: 187

Experts

1.	Caspi, Rachel R: 16 articles (01/2020 - 08/2002)
2.	Shao, Hui: 12 articles (12/2021 - 06/2003)
3.	Sun, Deming: 12 articles (12/2021 - 06/2003)
4.	Chan, Chi-Chao: 12 articles (08/2015 - 08/2002)
5.	Kaplan, Henry J: 10 articles (12/2021 - 08/2003)
6.	Silver, Phyllis B: 9 articles (08/2015 - 04/2003)
7.	Wildner, Gerhild: 6 articles (02/2018 - 09/2002)
8.	Chen, Jun: 5 articles (08/2021 - 01/2013)
9.	Diedrichs-Möhring, Maria: 5 articles (02/2018 - 01/2008)
10.	Jiang, Guomin: 4 articles (12/2021 - 09/2011)

Related Diseases

1.	Uveitis 01/01/2022 - "An experimental autoimmune uveitis (EAU) rat model induced by bovine interphotoreceptor retinoid-binding protein (IRBP) was used to mimic uveitis. " 01/01/2022 - "Multimodal evaluation of an interphotoreceptor retinoid-binding protein-induced mouse model of experimental autoimmune uveitis." 01/01/2020 - "Here, we show that homozygous TTPΔARE mice are resistant to the induction of experimental autoimmune uveitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP), an established model for human autoimmune (noninfectious) uveitis. " 10/01/2015 - "Col-Treg cells were administered intravenously in mice displaying experimental autoimmune uveitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) immunizations. " 01/01/2013 - "Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein."
2.	Inflammation (Inflammations) 12/01/2007 - "To verify that HO-1 is induced in EAU by interphotoreceptor retinoid-binding protein (IRBP), that an HO-1 inducers ameliorates the associated inflammation, and that an HO-1 inhibitor exacerbates this inflammation. " 09/25/2003 - "To investigate the changes of the GATA-3 expression and development of anterior chamber associated immune deviation (ACAID) after anterior chamber (AC) injection of interphotoreceptor retinoid binding protein (IRBP) under ocular inflammation. " 11/01/1986 - "All six monkeys immunized with bovine interphotoreceptor retinoid-binding protein developed ocular inflammation. " 11/01/2003 - "For example, in experimental autoimmune uveitis, immunization of naive rats with autologous interphotoreceptor retinoid-binding protein (IRBP) fails to induce intraocular inflammation or a strong T cell response, whereas bovine IRBP is a strong inducer of experimental autoimmune uveitis. " 03/01/1987 - "In our previous study rats immunized with bovine retinal interphotoreceptor retinoid-binding protein (IRBP) were found to develop inflammation in the eye and the pineal gland. "
3.	Autoimmune Diseases (Autoimmune Disease) 06/01/2006 - "Interphotoreceptor retinoid binding protein (IRBP)-induced experimental autoimmune uveoretinitis (EAU) is a CD4+ T cell-mediated autoimmune disease. " 04/01/2001 - "Experimental autoimmune uveoretinitis (EAU), which is a T cell mediated organ specific autoimmune disease, is induced by immunization with interphotoreceptor retinoid binding protein (IRBP) in susceptible strains of mice. " 07/01/2000 - "We used this principle to design a strategy for gene therapy of experimental autoimmune uveitis, a cell-mediated autoimmune disease model for human uveitis induced with the uveitogenic interphotoreceptor retinoid-binding protein (IRBP). " 10/31/2001 - "In this study, we investigated the potential role of NO as an immunoregulator to alter Th1/Th2 cytokine production, as well as to inhibit the interphotoreceptor retinoid binding protein (IRBP)-induced EAU, a CD4+ Th1 cell-mediated autoimmune disease. " 01/01/2008 - "Thymic expression of a photoreceptor cell antigen, interphotoreceptor retinoid-binding protein, is known to generate regulatory T cells (T(reg)) that prevent spontaneous autoimmune disease of the retina. "
4.	Pinealoma (Pineoblastoma) 09/01/1993 - "In this study, a pineal parenchymal tumor of the "mixed pineoblastoma/pineocytoma" type was examined for the expression of several photoreceptor, glial and neuronal proteins including: interphotoreceptor retinoid-binding protein (IRBP), rod opsin, cone opsin, S-Ag and cellular retinaldehyde-binding protein (CRA1BP). "
5.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 01/01/1996 - "The objective of this study was to determine the proliferative responses of peripheral blood lymphocytes of ocular antigens like retinal S-antigen, peptides M and G of S-antigen, yeast histone H3 peptide 106-121 homologous to peptide M and peptide R16 of interphotoreceptor retinoid binding protein (IRBP) in children with juvenile chronic arthritis (JCA). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Autoantigens
3.	Ligands
4.	Histocompatibility Antigens Class II
5.	Antigens
6.	Retinaldehyde (Retinal)
7.	Arrestin
8.	Proteins (Proteins, Gene)
9.	retinal S antigen peptide M
10.	Cytokines

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Intravitreal Injections
3.	Immunomodulation
4.	Intraperitoneal Injections