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apolipoprotein A-I Tangier
apolipoprotein A-I and isoforms found in patients with Tangier disease
Also Known As:
Tangier apo A-I; Tangier proapo A-I; apo A-I Tangier; apoA-I Tangier; pro-apo A-I Tangier; pro-apolipoprotein A-I Tangier; proapolipoprotein A-I Tangier
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Lipoproteins: 18361
Apolipoproteins: 14925
Apolipoproteins A: 1020
Apolipoprotein A-I: 3926
apolipoprotein A-I Tangier: 4
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Lipoproteins: 18361
Apolipoproteins: 14925
Apolipoproteins A: 1020
Apolipoprotein A-I: 3926
apolipoprotein A-I Tangier: 4
Apoproteins: 638
Apolipoproteins: 14925
Apolipoproteins A: 1020
Apolipoprotein A-I: 3926
apolipoprotein A-I Tangier: 4
Related Diseases
1.
Tangier Disease
10/15/1985 - "
These results are interpreted as indicating that there is no major structural defect in Tangier apo-A-I, and the rapid rate of catabolism of apo-A-I in Tangier disease is due to a post-translational defect in apo-A-I metabolism.
"
04/01/1982 - "
Tangier disease: a structural defect in apolipoprotein A-I (apoA-I Tangier).
"
10/01/1983 - "
These results suggest that the underlying defect in Tangier disease may be a faulty conversion of pro-apo A-I to mature apo A-I, either due to a defect in the converting enzyme activity or to a further specific structural defect in Tangier apo A-I. The failure of Tangier pro-apo A-I to associate with HDL may be at least partially responsible for the HDL deficiency in Tangier subjects.
"
11/01/1982 - "
These data are consistent with the concept that apoA-I(Tangier) is functionally and metabolically distinct from normal apoA-I, and is the cause of the striking hypercatabolism of apoA-I and apoA-II, and the lipoprotein abnormalities observed in Tangier disease.
"
04/01/1982 - "
These results have been interpreted as indicating that apoA-I Tangier has a different covalent structure than does normal apoA-I, and apoA-II Tangier is identical to normal apoA-II. This structural change in apoA-I Tangier is associated with rapid catabolism of apoA-I Tangier-and apoA-II Tangier-containing plasma lipoproteins, and it leads to the deficiency in high density lipoproteins, abnormal chylomicron remnants, and the intracellular accumulation of cholesterol ester characteristic of Tangier disease.
"
Related Drugs and Biologics
1.
Apolipoprotein A-I (Apolipoprotein A1)
2.
Apolipoprotein A-II (Apolipoprotein A2)
3.
Lipoproteins (Lipoprotein)
4.
Chylomicron Remnants
5.
HDL Lipoproteins
6.
Enzymes
7.
Cholesterol Esters (Cholesteryl Esters)