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prolyl-phenylalanyl-N-heptylargininamide

RN given refers to (D-Pro-L-Phe-L-Arg)-isomer

Also Known As:

Pro-Phe-N-heptyl-Arg-NH2; S 2441; S-2441; prolyl-phenylalanyl-N-heptylargininamide dihydrochloride

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - prolyl-phenylalanyl-N-heptylargininamide: 2

Related Diseases

1.	Bacteremia 01/01/1985 - "Efficacy of S-2441, a synthetic oligopeptide, in a rat model for gram-negative bacteremia." 01/01/1985 - "The results indicate that S-2441 affords protection in lethal gram-negative bacteremia owing in part to attenuation of disseminated intravascular coagulation and complement-mediated reactions. "
2.	Pancreatitis 06/01/1984 - "Pancreatitis-induced fibrinolysis was inhibited by S-2441 suggesting that synthetic protease inhibitors may play a therapeutic role in pancreatitis." 06/01/1984 - "With the induction of pancreatitis (group II), serum amylase was significantly elevated but fibrinogen only became elevated at 24 hr and PTT at 48 hr. The increase in B beta 15-42 IP seen 30 min after induction of pancreatitis and the decrease in alpha 2-antiplasmin were blunted by aprotinin, alpha 1-antitrypsin, and S-2441, but inhibition of the rise in amylase and B beta 15-42 IP only reached significance with S-2441 (P less than 0.05). " 06/01/1984 - "Twenty minutes after bile-induced pancreatitis, group III was given 1.0 mg/kg aprotinin (trasylol), group IV was given 10 mg/kg S-2441, a new synthetic protease inhibitor, and group V was given 0.5 mg/kg alpha 2-antitrypsin by intravenous infusion over 10 min. Blood was drawn for amylase, protime (PT), partial thromboplastin time (PTT), fibrinogen, and platelets, in addition to markers of hypercoagulation, fibrinopeptide A, and antithrombin III, and markers of fibrinolysis, B beta 15-42 immunoreactive peptide (IP), and alpha 2-antiplasmin at baseline, 1/2, 1, 3, 6, 24, 48, and 72 hr after duodenotomy or bile injection. "
3.	Necrosis 01/01/1985 - "Ultrastructural evaluation of the liver demonstrated that S-2441 prevented the development of extensive sinusosoidal microthrombosis and hepatocellular necrosis. "
4.	Disseminated Intravascular Coagulation 01/01/1985 - "The results indicate that S-2441 affords protection in lethal gram-negative bacteremia owing in part to attenuation of disseminated intravascular coagulation and complement-mediated reactions. "

Related Drugs and Biologics

1.	Oligopeptides
2.	Protease Inhibitors (Protease Inhibitor)
3.	Peptides (Polypeptides)
4.	Aprotinin (Trasylol)
5.	Fibrinopeptide A
6.	Fibrinogen (Factor I)
7.	Complement System Proteins (Complement)
8.	Antithrombin III
9.	Amylases
10.	alpha 1-Antitrypsin (alpha 1 Antitrypsin)

Related Therapies and Procedures

1.	Intravenous Infusions