terbinafine (Lamisil)

synthetic antifungal agent inhibiting fungal squalene epoxidase; structure given in first source; RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 1/85

Also Known As:

Networked: 901 relevant articles (240 outcomes, 212 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gupta, Aditya K: 22 articles (09/2015 - 04/2002)
2.	Gupta, A K: 16 articles (03/2013 - 01/2000)
3.	Tavakkol, Amir: 8 articles (06/2014 - 05/2005)
4.	Cooper, Elizabeth A: 7 articles (05/2013 - 07/2003)
5.	Paquet, Maryse: 6 articles (05/2015 - 02/2013)
6.	Paul, C: 6 articles (12/2012 - 01/2001)
7.	Korting, H C: 6 articles (01/2008 - 02/2001)
8.	Baran, R: 5 articles (03/2015 - 06/2000)
9.	Sigurgeirsson, B: 5 articles (03/2013 - 09/2003)
10.	Warshaw, Erin M: 5 articles (03/2007 - 09/2003)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 09/01/2004 - "The accepted regimen for terbinafine, one of the most effective treatments for dermatophyte onychomycosis, is continuous administration of 250 mg/day over 16 weeks. " 02/15/2001 - "Continuous oral terbinafine therapy is most effective against dermatophytes, which are responsible for the majority of onychomycosis cases. " 01/01/2000 - "With regard to continuous oral antifungal regimens, terbinafine therapy has been found to be most cost effective in the treatment of toenail onychomycosis, with a drug acquisition cost of $US522.50. " 10/01/2009 - "Terbinafine is an excellent choice in diabetics due to its low risk of drug-drug interaction and proven efficacy against the typical pathogens that cause onychomycosis. " 06/01/2010 - "The pharmacologic and pharmacokinetic properties of terbinafine give strong support to the possibility that the pulse therapy may be equally effective in onychomycoses, possibly reducing medication costs and drug exposure. "
2.	Infection 01/01/1999 - "The results of this study confirm that oral terbinafine is safe and highly effective for the short-term treatment of fungal skin infections." 11/01/2012 - "Terbinafine is the most frequently used systemic antimycotic and antifungal medication, reflecting its superior efficacy for dermatophyte infections. " 04/01/2015 - "Reduction in the immunosuppression and treatment with terbinafine cleared the P. romeroi infection, while lowering immunosuppression and changing the type of immunosuppressive therapy were important steps in the successful management of the KS. " 08/01/2012 - "Although bioavailability was low, excellent penetration at the site of infection and low minimum inhibitory concentrations values provided terbinafine with good efficacy against dermatophyte infections." 10/01/2005 - "Response rates to existing therapy are lower than optimal, but newer agents like terbinafine hold promise for improved management of such infections. "
3.	Tinea Pedis (Athlete's Foot) 09/01/2001 - "In most cases, one week of therapy with topical terbinafine is effective for interdigital tinea pedis. " 10/01/1990 - "We conclude that terbinafine is well tolerated and highly effective in moccasin-type tinea pedis." 01/01/2008 - "To study and establish an optimal administration method of oral antifungal, terbinafine (TBF), for hyperkeratotic type tinea pedis, from the pharmacokinetic point of view, 20 patients with hyperkeratotic type tinea pedis were given TBF 125 mg once daily for 4 weeks and observed over time for improvement in dermatological symptoms and mycological efficacy. " 01/01/2007 - "Terbinafine is very well tolerated in any topical pharmaceutical formulation and also has high efficacy as a cure for tinea pedis, irrespective of type of pharmaceutical formulation, treatment duration, and frequency of application, including the recently established one-shot regimen. " 01/01/2008 - "Thus, we conclude that the high efficacy of short-term treatment with terbinafine in patients with tinea pedis is possible due to its fungicidal activity coupled with a distinct reservoir formation in the upper layers of the epidermis."
4.	Tinea (Ringworm) 11/01/1994 - "Our results show that 1-week therapy with oral terbinafine is highly effective in the treatment of tinea cruris/corporis." 11/01/1994 - "To evaluate the efficacy of short-term therapy with oral terbinafine in cases of tinea cruris/corporis, 22 patients (21 male and one female) with mycologically proven tinea cruris/corporis, were included in the present study. " 01/01/1997 - "We conclude that a 1-week course of Lamisil 1% emulsion gel is significantly more effective in the treatment of tinea corporis/cruris than placebo gel in respect of complete cure, mycological cure and effective treatment." 02/01/1992 - "High cure rates have been obtained in a preliminary study with oral terbinafine, 0.25 g/d, for 12 months, which have cleared toenail tinea in 15 of 17 patients. " 10/01/2014 - "Our findings suggest that in vivo potency and efficacy of AS2077715 are equal to or greater than that of terbinafine, positioning AS2077715 as a good candidate for use in treating trichophytosis. "
5.	Tinea Capitis 07/01/1996 - "In our opinion, terbinafine given for 1, 2 or 4 weeks, is equally effective for most cases of tinea capitis." 05/01/1995 - "Terbinafine was shown to be very effective (93% cured), in the treatment of children with tinea capitis, using a shorter treatment duration (4 weeks) than that usually employed with presently available antifungal drugs. " 01/01/1998 - "Terbinafine pulse therapy was found to be effective and safe in the treatment of tinea capitis in an open study of 13 children (age range 3-13 years, mean 6.4 years, 7 males, 6 females, Tricohphyton tonsurans 7 patients, T. " 11/01/2015 - "Tinea capitis is effectively treated with terbinafine. " 04/01/2002 - "Terbinafine has been shown to be effective in tinea capitis, using different treatment durations. "

Related Drugs and Biologics

1.	Itraconazole (Sporanox)
2.	Griseofulvin (Grifulvin V)
3.	Fluconazole (Zonal)
4.	Allylamine
5.	terbinafine (Lamisil)
6.	amorolfine
7.	Ketoconazole (Nizoral)
8.	ciclopirox (Loprox)
9.	Antifungal Agents
10.	Clotrimazole (Lotrimin)

Related Therapies and Procedures

1.	Debridement
2.	Solid-State Lasers
3.	Peritoneal Dialysis
4.	Aftercare (After-Treatment)
5.	Transplants (Transplant)