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valproic acid glucuronide

major metabolite of valproic acid

Also Known As:

VPAG

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Valerates: 135
      - Pentanoic Acids: 1
        Valproic Acid: 9766
        valproic acid glucuronide: 12
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Valerates: 135
      - Pentanoic Acids: 1
        Valproic Acid: 9766
        valproic acid glucuronide: 12

Experts

1.	Antunes-Rodrigues, José: 1 article (01/2021)
2.	Busnardo, Cristiane: 1 article (01/2021)
3.	Corrêa, Fernando M A: 1 article (01/2021)
4.	Crestani, Carlos C: 1 article (01/2021)
5.	Fassini, Aline: 1 article (01/2021)
6.	Rodrigues, Bruno: 1 article (01/2021)
7.	Chen, Xuyi: 1 article (01/2020)
8.	Gong, Yinan: 1 article (01/2020)
9.	Guo, Yi: 1 article (01/2020)
10.	Guo, Yongming: 1 article (01/2020)

Related Diseases

1.	Hypercapnia 08/01/2012 - "The present study assessed the effect of chemical lesion of the dorsolateral and dorsomedial and ventrolateral/lateral PAG (dlPAG, dmPAG, and vPAG, respectively) on cardiorespiratory and thermal responses to hypercapnia. " 08/01/2012 - "The results suggest that dlPAG, dmPAG, and vPAG modulate hypercapnic ventilatory responses in rats but do not affect MAP, HR, or Tb regulation in resting conditions or during hypercapnia."
2.	Pain (Aches) 01/01/2022 - "We observed that Nav1.8 neurons from the bed nuclei of the stria terminalis (BST), amygdala, and the periaqueductal gray (vPAG) are sensitive to noxious stimuli from an experimental model of chronic inflammatory pain. " 04/01/1996 - "These results indicate that the dose of morphine administered into the vPAG determines the contribution of spinopetal projections in inhibiting dorsal horn neurons involved in reflex generation versus the rostral transmission of pain information. " 06/06/1994 - "In addition, the results indicate that different cholinergic substrates in the PAG may mediate both alpha-adrenergic and non-alpha-adrenergic descending pain mechanisms activated by the dPAG and vPAG, respectively." 01/01/2016 - "Given the dense expression of mu opioid receptors and the role of dopamine in pain, the recently characterized dopamine neurons in the ventral PAG (vPAG)/dorsal raphe (DR) region are a potentially critical site for the antinociceptive actions of opioids. "
3.	Shock 12/24/1990 - "Independent groups of animals received microinjections of either 5.0 micrograms naltrexone HCl or vehicle into the vPAG prior to being placed in an observation chamber in which shock had been delivered 24 h earlier. " 04/01/1996 - "The capacity of morphine microinjected into the ventrolateral periaqueductal gray (vPAG) to elevate the thresholds of spinal motor reflexes (SMRs), vocalizations during shock (VDSs) and vocalization afterdischarges (VADs) was challenged by the intrathecal administration of receptor antagonists to serotonin (methysergide), norepinephrine (phentolamine) and mu-opiates (naloxone). "
4.	Panic Disorder (Panic Attack) 03/16/2010 - "These findings suggest that GABA mechanisms are involved in the mediation of antinociception and behavioral inhibition to aversive stimulation of the vPAG and exert powerful control over the neural substrates of fear in the dPAG to prevent a full-blown defense reaction possibly associated with panic disorder."
5.	Hemorrhagic Shock 01/01/2021 - "Moreover, hemorrhagic shock caused a decrease in NOx levels in the paraventricular nucleus of the hypothalamus (PVN), amygdala, bed nucleus of the stria terminalis (BNST), and ventral periaqueductal gray matter (vPAG). "

Related Drugs and Biologics

1.	Opiate Alkaloids
2.	Cholinergic Agents (Cholinergics)
3.	Adrenergic Agents (Adrenergic Drugs)
4.	mu Opioid Receptors (mu Opioid Receptor)
5.	Serotonin (5 Hydroxytryptamine)
6.	Phentolamine (Z-Max)
7.	Norepinephrine (Noradrenaline)
8.	Naltrexone (ReVia)
9.	Naloxone (Narcan)
10.	Morphine (MS Contin)