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clomesone
structure & RN given in first source
Also Known As:
2-CMSMS; 2-chloroethyl-(methylsulfonyl)methanesulfonate; NSC 33947; NSC-338947; clomesome
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Acyclic Hydrocarbons
Alkanes: 241
Alkanesulfonic Acids
Alkanesulfonates: 9
Mesylates: 334
clomesone: 4
Sulfur Compounds: 278
Sulfur Acids
Sulfonic Acids: 1605
Alkanesulfonic Acids
Alkanesulfonates: 9
Mesylates: 334
clomesone: 4
Related Diseases
1.
Leukemia P388
12/01/1993 - "
Therefore, several 2-chloroethyl alpha-substituted methanesulfonates are less effective against P388 leukemia than is the alpha-(methylsulfonyl) derivative (clomesone), and several substituted alkyl (methylsulfonyl)methanesulfonates are also less effective than is the 2-chloroethyl derivative (clomesone).
"
12/01/1993 - "
2-Hydroxyethyl (methylsulfonyl)methanesulfonate was active against P388 leukemia (increases in lifespan, 66 and 94%), but was less effective than clomesone, which effects cures.
"
03/01/1989 - "
Clomesone also exhibited activity against other murine tumors (P388 leukemia, B16 melanoma, Lewis lung carcinoma, and M5076 sarcoma).
"
2.
Neoplasms (Cancer)
03/01/1989 - "
Clomesone is generally as effective as the chloroethylnitrosoureas against experimental tumor models.
"
03/01/1989 - "
Clomesone was evaluated for antitumor activity against a spectrum of animal tumor models.
"
03/01/1989 - "
Antitumor activity of 2-chloroethyl (methylsulfonyl)methanesulfonate (clomesone, NSC 33847) against selected tumor systems in mice.
"
03/01/1989 - "
Clomesone also exhibited activity against other murine tumors (P388 leukemia, B16 melanoma, Lewis lung carcinoma, and M5076 sarcoma).
"
07/01/1991 - "
The sensitivity of human colon tumor cells, HT29, to the chloroethylating agents, 1,3-bis(2-chloroethyl)-1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, 2-chloroethyl(methylsulfonyl) methanesulfonate (clomesone), and chlorozotocin was increased by pretreatment for 2 h with 25 microM of each analogue.
"
3.
Lewis Lung Carcinoma
03/01/1989 - "
Clomesone also exhibited activity against other murine tumors (P388 leukemia, B16 melanoma, Lewis lung carcinoma, and M5076 sarcoma).
"
4.
Colorectal Neoplasms (Colorectal Cancer)
03/01/1993 - "
Clomesone exhibited no activity in vitro against the majority of cell lines derived from solid human colorectal carcinomas.
"
5.
Sarcoma (Soft Tissue Sarcoma)
03/01/1989 - "
Clomesone also exhibited activity against other murine tumors (P388 leukemia, B16 melanoma, Lewis lung carcinoma, and M5076 sarcoma).
"
Related Drugs and Biologics
1.
Mesylates (Mesylate)
2.
methanesulfonic acid (methanesulfonate)
3.
Carmustine (FIVB)
4.
chlorozotocin