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rilmazafone

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structure given in first source; RN given refers to parent cpd

Also Known As:

1-(2-(2-chlorobenzoyl)-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole hydrochloride; 450191-S; S 450191; S-450191; rilmazafone hydrochloride; 1H-1,2,4-Triazole-3-carboxamide, 5-(((aminoacetyl)amino)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-, monohydrochloride

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Triazoles: 187
      - rilmazafone: 5

Experts

1.	Ogawa, Y: 1 article (09/2007)
2.	Kadekawa, K: 1 article (09/2007)
3.	Sugaya, K: 1 article (09/2007)
4.	Miyazato, M: 1 article (09/2007)
5.	Nishijima, S: 1 article (09/2007)

Related Diseases

1.	Nocturia 09/01/2007 - "Melatonin and rilmazafone were equally effective for nocturia in the elderly. " 09/01/2007 - "We compared the effects of melatonin, an antioxidant and sleep inducer in humans, and rilmazafone hydrochloride, a hypnotic, in elderly patients with nocturia. " 09/01/2007 - "Effects of melatonin and rilmazafone on nocturia in the elderly."
2.	Seizures (Seizure) 08/01/1984 - "In the protection from maximal electroshock convulsions (MEC), the potency of phenytoin was significantly decreased by 450191-S and triazolam. " 08/01/1984 - "The potencies of 450191-S and nitrazepam in preventing pentetrazol convulsions were markedly decreased by aminopyrine, whereas that of estazolam was remarkably increased by phenytoin. " 07/01/1984 - "Anti-pentylenetetrazol, picrotoxin and bicuculline convulsions of 450191-S had the same potency as nitrazepam, but caused much less anti-electroshock convulsion than the BDZ. "
3.	Ataxia (Dyssynergia) 07/01/1984 - "These results indicate that 450191-S possesses inhibitory effects on the central nervous system, including a potent sleep-inducing effect, and is characterized by markedly weak muscle relaxant activity and motor incoordination." 05/15/1984 - "These results indicate that the pharmacological activity of 450191-S is largely due to the action of active metabolites, although some points remain to be elucidated to fully account for the large attenuation of the side effect (ataxia) compared with the major effects (anti-convulsant and hypnotic). " 07/01/1984 - "Oral administration of 450191-S consistently caused sedation without excitability in mice and rats, and it was only 1/2 to 1/266 as potent as the BDZ in producing motor incoordination as assessed by traction, rotarod performance and inclined screen tests in mice, induced much less ataxia in cats and monkeys, and inhibited respiration in anesthetized cats. "
4.	Substance-Related Disorders (Drug Abuse) 01/01/1984 - "These results suggest that 450191-S possesses little, if any, drug dependence liability of the tranquilizer type."
5.	Weight Loss (Weight Reduction) 01/01/1984 - "Abrupt withdrawal of 450191-S caused the same slight weight loss and moderate decrease in food intake as those seen with diazepam and nitrazepam, and cross-physical dependence between 450191-S and diazepam was found. "

Related Drugs and Biologics

1.	Melatonin
2.	Nitrazepam (Serenade)
3.	Triazolam (Halcion)
4.	Picrotoxin
5.	Phenytoin (Dilantin)
6.	Pentylenetetrazole (Metrazol)
7.	Estazolam (ProSom)
8.	Diazepam (Valium)
9.	Bicuculline
10.	Aminopyrine (Aminophenazone)

Related Therapies and Procedures

1.	Traction
2.	Oral Administration