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bis(4-methylumbelliferyl)pyrophosphate

phosphodiesterase substrate

Also Known As:

BMPP; Diphosphoric acid, P,P'-bis(4-methyl-2-oxo-2H-1-benzopyran-7-yl) ester

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        bis(4-methylumbelliferyl)pyrophosphate: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        bis(4-methylumbelliferyl)pyrophosphate: 4

Experts

1.	Abue, Makoto: 1 article (01/2021)
2.	Asada, Yukinori: 1 article (01/2021)
3.	Fujimori, Haruna: 1 article (01/2021)
4.	Imai, Takayuki: 1 article (01/2021)
5.	Ito, Ryo: 1 article (01/2021)
6.	Iwai, Wataru: 1 article (01/2021)
7.	Katayose, Yu: 1 article (01/2021)
8.	Katori, Yukio: 1 article (01/2021)
9.	Kawamura, Sadafumi: 1 article (01/2021)
10.	Matsuura, Kazuto: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Thus, the identification of BMPP as a potential CSC suppressor provides scope for the development of novel therapeutic modalities for the treatment of cancers with BEX2 overexpressing CSCs." 03/26/2018 - "Our study showed that EpCAM functionalized BMPP-Pt loaded MSNPs can efficiently internalize and induce apoptosis of cancer cells as well as show strong intracellular fluorescence. " 01/01/2021 - "BMPP was found to exert decreasing effects on BEX2 protein expression and G0 phase population of the tumor cells, and increasing effects on ATP levels and chemotherapeutic sensitivity of the cells. " 03/26/2018 - "BMPP-Pt was found to exhibit a high AIE property with emission maxima at 497 nm. For more efficient cancer cell targeting, BMPP-Pt was encapsulated into mesoporous silica nanoparticles (Pt-MSNPs) and the MSNPs were further surface modified with an anti-EpCAM aptamer (Pt-MSNP-E). "
2.	Cholangiocarcinoma 01/01/2021 - "We screened 9600 small chemical compounds in high-throughput screening using cholangiocarcinoma cell line HuCCT1 expressing BEX2 protein fused with NanoLuc, and identified a compound, BMPP (1, 3-Benzenediol, [4-(4-methoxyphenyl)-1H-pyrazol-3-yl]). "
3.	Radiculopathy (Radiculopathy, Cervical) 09/15/2013 - "To assess clinical outcomes, perioperative complications, revision surgery rates, and recombinant human bone morphogenetic protein-2 (BMP-2)-related osteolysis, heterotopic bone, and unexplained postoperative radiculitis (BMPP) in a group of patients treated with BMP-2-augmented transforaminal lumbar interbody fusion (bTLIF) for the homogeneous diagnosis of discogenic pain syndrome (DPS) and to put forth the algorithm used to make the diagnosis. "
4.	Pain (Aches) 09/15/2013 - "To assess clinical outcomes, perioperative complications, revision surgery rates, and recombinant human bone morphogenetic protein-2 (BMP-2)-related osteolysis, heterotopic bone, and unexplained postoperative radiculitis (BMPP) in a group of patients treated with BMP-2-augmented transforaminal lumbar interbody fusion (bTLIF) for the homogeneous diagnosis of discogenic pain syndrome (DPS) and to put forth the algorithm used to make the diagnosis. "
5.	Osteolysis 09/15/2013 - "To assess clinical outcomes, perioperative complications, revision surgery rates, and recombinant human bone morphogenetic protein-2 (BMP-2)-related osteolysis, heterotopic bone, and unexplained postoperative radiculitis (BMPP) in a group of patients treated with BMP-2-augmented transforaminal lumbar interbody fusion (bTLIF) for the homogeneous diagnosis of discogenic pain syndrome (DPS) and to put forth the algorithm used to make the diagnosis. "

Related Drugs and Biologics

1.	Epithelial Cell Adhesion Molecule
2.	Silicon Dioxide (Silica)
3.	Proteins (Proteins, Gene)
4.	Phosphoric Diester Hydrolases (Phosphodiesterases)
5.	Adenosine Triphosphate (ATP)
6.	recombinant human bone morphogenetic protein-2
7.	nanoluc

Related Therapies and Procedures

1.	Reoperation