prothymosin alpha

11/01/2008 - "Immunocytological and preliminary immunohistochemical studies of prothymosin alpha, a human cancer-associated polypeptide, with a well-characterized polyclonal antibody."
05/01/2012 - "Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy."
11/01/2008 - "Prothymosin alpha (ProTalpha) is a nuclear polypeptide of great biological and, possibly clinical, importance, because its expression levels have been associated with early diagnosis/prognosis of human cancer. "
07/01/2008 - "Overexpression of the nuclear oncoprotein prothymosin a enhanced and, in a reciprocal experiment, down-regulation of endogenous prothymosin alpha by RNA interference approach inhibited transcriptional activity of the p53 tumor suppressor in the reporter gene assay. "
07/01/2008 - "[Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor]."

01/01/2009 - "Aberrant prothymosin-alpha expression in human bladder cancer."
02/01/2006 - "Our findings have revealed that urine prothymosin-alpha has the potential of being a useful tumor marker for the detection and follow-up of bladder cancer."
02/01/2006 - "Urine prothymosin-alpha as novel tumor marker for detection and follow-up of bladder cancer."
01/01/2009 - "To investigate the prothymosin-alpha (PTMA) expression in human bladder cancer using tissue microarrays. "
11/01/2001 - "To explore the potential use of prothymosin alpha(ProT), a putative thymic hormone, in gene therapy for bladder cancer, we generated a replication-defective recombinant retroviral vector encoding ProT and tested its antitumor effect on the MBT-2 murine bladder cancer. "

12/01/2005 - "Previously, we showed that murine prothymosin alpha (ProT) enhances the efficacy of a pseudorabies DNA vaccine delivered by bacterial vectors. "
07/16/2001 - "Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis."

01/01/1993 - "In 71 patients with classic invasive ductal carcinomas, levels of prothymosin alpha (PT alpha), as assayed by a radioimmunoassay that detects thymosin alpha 1 (the NH2-terminal fragment of PT alpha), were significantly greater in tumour samples than in normal breast tissue. "

02/01/2006 - "The mean value of urine prothymosin-alpha in healthy volunteers was 0.68 +/- 0.13 ng/mL. Regardless of the presence of urinary tract infection, the urine prothymosin-alpha level in patients with newly diagnosed, as yet untreated, bladder cancer was significantly greater than that in those who were tumor free after curative treatment (P = 0.050 and P = 0.026 for the presence and absence of urinary tract infection, respectively). "