leukotriene B4 20-hydroxylase

a cytochrome P-450 enzyme that catalyzes omega-hydroxylation of leukotriene-B4

Also Known As:

LTB4 omega hydroxylase; leukotriene B4 omega hydroxylase

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 4: 21
        leukotriene B4 20-hydroxylase: 4
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 4: 21
      - leukotriene B4 20-hydroxylase: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 4: 21
        leukotriene B4 20-hydroxylase: 4

Related Diseases

1.	Inflammation (Inflammations) 09/01/1999 - "Human liver leukotriene B4 (LTB4) omega-hydroxylase (CYP4F2) plays an important role in the metabolic inactivation and degradation of LTB4, a potent mediator of inflammation. " 10/25/1985 - "Potent suicidal inhibitors of the LTB4 omega-hydroxylase in human PMN will help elucidate the roles played by LTB4 and its omega-oxidation products in regulating PMN function and in mediating inflammation."
2.	Ulcerative Colitis 01/01/1995 - "LTB4 omega-hydroxylase activity is an important factor in regulating LTB4 level in colonic mucosa, and the increased LTB4 level in inflamed mucosa with IBD, especially ulcerative colitis, is caused by decreased LTB4 omega-hydroxylase activity and increased 5-lipoxygenase activity." 07/01/1993 - "To determine how LTB4 omega-hydroxylase is modulated in inflammatory bowel disease, we investigated the kinetic characteristics of this enzyme in 10 patients with Crohn's disease (CD), nine with ulcerative colitis (UC) and eight healthy control subjects. "
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/01/1993 - "Leukotriene B4 omega-hydroxylase activity in polymorphonuclear leukocytes from patients with inflammatory bowel disease." 07/01/1993 - "To determine how LTB4 omega-hydroxylase is modulated in inflammatory bowel disease, we investigated the kinetic characteristics of this enzyme in 10 patients with Crohn's disease (CD), nine with ulcerative colitis (UC) and eight healthy control subjects. "
4.	Crohn Disease (Crohn's Disease) 07/01/1993 - "To determine how LTB4 omega-hydroxylase is modulated in inflammatory bowel disease, we investigated the kinetic characteristics of this enzyme in 10 patients with Crohn's disease (CD), nine with ulcerative colitis (UC) and eight healthy control subjects. "

Related Drugs and Biologics

1.	Leukotriene B4
2.	Enzymes
3.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)