spiroplatin

01/01/1986 - "In this study TNO-6 had no anti-tumour activity in gastrointestinal malignancy, but produced significant renal tubular damage."
01/01/1992 - "64 Patients with nine different solid tumors received 141 cycles of spiroplatin at a dose of 30 mg/m2 every 3 weeks. "
01/01/1986 - "The kinetics of intratumoral uptake of cisplatin, carboplatin (CBDCA) and TNO-6 were studied in vitro in fragments of tumors of the head and neck maintained in culture medium under conditions simulating therapeutic conditions of chemo-embolization. "
01/01/1990 - "Comparative effect of cisplatin, spiroplatin, carboplatin and iproplatin in a human tumor clonogenic assay."
01/01/1990 - "A modified double-layer Hamburger and Salmon cloning assay was used to test cisplatin and its analogs (spiroplatin, carboplatin and iproplatin) on fresh tumor samples from 63 patients with a variety of non-hematological malignancies. "

06/01/1986 - "Phase II study of the platinum analog TNO-6 in patients with advanced ovarian cancer."

08/01/1987 - "Severe proteinuria was observed in all three dogs treated with TNO-6. "
11/01/1984 - "Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. "

01/01/1986 - "Marcellomycin and the platinum complexes cisplatin, carboplatin, and spiroplatin did not cause neutropenia at maximum tolerated doses. "
01/01/1985 - "Known myelosuppressive drugs such as mitomycin C, doxorubicin, and BCNU, as well as the false negatives from the mouse neutropenia model (cisplatin, carboplatin, spiroplatin, and marcellomycin) caused marked inhibition of colony formation 24 h after dosing; bleomycin was inactive. "

10/01/1983 - "With regard to toxicity, repeated administration of TNO-6 (1.0 mg/kg twice a week for 7 weeks) induced less decrease of body weight than did cis-DDP. "
10/01/1983 - "administration of cis-DDP and TNO-6 reached its maximum at a dose of 1.0 mg/kg body weight (twice a week for 7 weeks). "
11/01/1984 - "Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. "